PTPRN2

Protein tyrosine phosphatase, receptor type, N polypeptide 2, also known as PTPRN2, is a human gene.cite web | title = Entrez Gene: PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5799| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.cite web | title = Entrez Gene: PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5799| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lan MS, Lu J, Goto Y, Notkins AL |title=Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. |journal=DNA Cell Biol. |volume=13 |issue= 5 |pages= 505–14 |year= 1994 |pmid= 8024693 |doi=
*cite journal | author=Cui L, Yu WP, DeAizpurua HJ, "et al." |title=Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24817–23 |year= 1996 |pmid= 8798755 |doi=
*cite journal | author=Kawasaki E, Hutton JC, Eisenbarth GS |title=Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes. |journal=Biochem. Biophys. Res. Commun. |volume=227 |issue= 2 |pages= 440–7 |year= 1996 |pmid= 8878534 |doi= 10.1006/bbrc.1996.1526
*cite journal | author=Smith PD, Barker KT, Wang J, "et al." |title=ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins. |journal=Biochem. Biophys. Res. Commun. |volume=229 |issue= 2 |pages= 402–11 |year= 1997 |pmid= 8954911 |doi= 10.1006/bbrc.1996.1817
*cite journal | author=Nagase T, Ishikawa K, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=
*cite journal | author=Li Q, Borovitskaya AE, DeSilva MG, "et al." |title=Autoantigens in insulin-dependent diabetes mellitus: molecular cloning and characterization of human IA-2 beta. |journal=Proc. Assoc. Am. Physicians |volume=109 |issue= 4 |pages= 429–39 |year= 1997 |pmid= 9220540 |doi=
*cite journal | author=Schmidli RS, Colman PG, Cui L, "et al." |title=Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM. |journal=Autoimmunity |volume=28 |issue= 1 |pages= 15–23 |year= 1998 |pmid= 9754810 |doi=
*cite journal | author=van den Maagdenberg AM, Schepens JT, Schepens MT, "et al." |title=Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 3-4 |pages= 153–5 |year= 1999 |pmid= 9858807 |doi=
*cite journal | author=Berghs S, Aggujaro D, Dirkx R, "et al." |title=betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system. |journal=J. Cell Biol. |volume=151 |issue= 5 |pages= 985–1002 |year= 2001 |pmid= 11086001 |doi=
*cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kubosaki A, Gross S, Miura J, "et al." |title=Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice. |journal=Diabetes |volume=53 |issue= 7 |pages= 1684–91 |year= 2004 |pmid= 15220191 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032

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