PTPRK

Protein tyrosine phosphatase, receptor type, K, also known as PTPRK, is a human gene.cite web | title = Entrez Gene: PTPRK protein tyrosine phosphatase, receptor type, K| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5796| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.cite web | title = Entrez Gene: PTPRK protein tyrosine phosphatase, receptor type, K| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5796| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zondag GC, Koningstein GM, Jiang YP, "et al." |title=Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14247–50 |year= 1995 |pmid= 7782276 |doi=
*cite journal | author=Sap J, Jiang YP, Friedlander D, "et al." |title=Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding. |journal=Mol. Cell. Biol. |volume=14 |issue= 1 |pages= 1–9 |year= 1994 |pmid= 8264577 |doi=
*cite journal | author=Fuchs M, Müller T, Lerch MM, Ullrich A |title=Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. |journal=J. Biol. Chem. |volume=271 |issue= 28 |pages= 16712–9 |year= 1996 |pmid= 8663237 |doi=
*cite journal | author=Yang Y, Gil M, Byun SM, "et al." |title=Transforming growth factor-beta1 inhibits human keratinocyte proliferation by upregulation of a receptor-type tyrosine phosphatase R-PTP-kappa gene expression. |journal=Biochem. Biophys. Res. Commun. |volume=228 |issue= 3 |pages= 807–12 |year= 1997 |pmid= 8941358 |doi= 10.1006/bbrc.1996.1736
*cite journal | author=Yang Y, Gil MC, Choi EY, "et al." |title=Molecular cloning and chromosomal localization of a human gene homologous to the murine R-PTP-kappa, a receptor-type protein tyrosine phosphatase. |journal=Gene |volume=186 |issue= 1 |pages= 77–82 |year= 1997 |pmid= 9047348 |doi=
*cite journal | author=Zhang Y, Siebert R, Matthiesen P, "et al." |title=Cytogenetical assignment and physical mapping of the human R-PTP-kappa gene (PTPRK) to the putative tumor suppressor gene region 6q22.2-q22.3. |journal=Genomics |volume=51 |issue= 2 |pages= 309–11 |year= 1998 |pmid= 9722959 |doi= 10.1006/geno.1998.5323
*cite journal | author=McArdle L, Rafferty M, Maelandsmo GM, "et al." |title=Protein tyrosine phosphatase genes downregulated in melanoma. |journal=J. Invest. Dermatol. |volume=117 |issue= 5 |pages= 1255–60 |year= 2001 |pmid= 11710941 |doi= 10.1046/j.0022-202x.2001.01534.x
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Novellino L, Renkvist N, Rini F, "et al." |title=Identification of a mutated receptor-like protein tyrosine phosphatase kappa as a novel, class II HLA-restricted melanoma antigen. |journal=J. Immunol. |volume=170 |issue= 12 |pages= 6363–70 |year= 2003 |pmid= 12794170 |doi=
*cite journal | author=Anderson NL, Polanski M, Pieper R, "et al." |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311–26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200
*cite journal | author=Goehler H, Lalowski M, Stelzl U, "et al." |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016
*cite journal | author=Xu Y, Tan LJ, Grachtchouk V, "et al." |title=Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 42694–700 |year= 2006 |pmid= 16263724 |doi= 10.1074/jbc.M507722200
*cite journal | author=Eswaran J, Debreczeni JE, Longman E, "et al." |title=The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1. |journal=Protein Sci. |volume=15 |issue= 6 |pages= 1500–5 |year= 2006 |pmid= 16672235 |doi= 10.1110/ps.062128706
*cite journal | author=Xu Y, Shao Y, Voorhees JJ, Fisher GJ |title=Oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes. |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 27389–97 |year= 2006 |pmid= 16849327 |doi= 10.1074/jbc.M602355200

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