PTPRG

Protein tyrosine phosphatase, receptor type, G, also known as PTPRG, is a human gene.cite web | title = Entrez Gene: PTPRG protein tyrosine phosphatase, receptor type, G| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5793| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.cite web | title = Entrez Gene: PTPRG protein tyrosine phosphatase, receptor type, G| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5793| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=LaForgia S, Morse B, Levy J, "et al." |title=Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 11 |pages= 5036–40 |year= 1991 |pmid= 1711217 |doi=
*cite journal | author=Kaplan R, Morse B, Huebner K, "et al." |title=Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 18 |pages= 7000–4 |year= 1990 |pmid= 2169617 |doi=
*cite journal | author=Krueger NX, Streuli M, Saito H |title=Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. |journal=EMBO J. |volume=9 |issue= 10 |pages= 3241–52 |year= 1990 |pmid= 2170109 |doi=
*cite journal | author=Latif F, Tory K, Modi W, "et al." |title=A MspI polymorphism and linkage mapping of the human protein-tyrosine phosphatase G (PTPRG) gene. |journal=Hum. Mol. Genet. |volume=2 |issue= 1 |pages= 91 |year= 1993 |pmid= 7683956 |doi=
*cite journal | author=Barnea G, Silvennoinen O, Shaanan B, "et al." |title=Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases. |journal=Mol. Cell. Biol. |volume=13 |issue= 3 |pages= 1497–506 |year= 1993 |pmid= 8382771 |doi=
*cite journal | author=Kastury K, Ohta M, Lasota J, "et al." |title=Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation. |journal=Genomics |volume=32 |issue= 2 |pages= 225–35 |year= 1997 |pmid= 8833149 |doi= 10.1006/geno.1996.0109
*cite journal | author=van Niekerk CC, Poels LG |title=Reduced expression of protein tyrosine phosphatase gamma in lung and ovarian tumors. |journal=Cancer Lett. |volume=137 |issue= 1 |pages= 61–73 |year= 1999 |pmid= 10376795 |doi=
*cite journal | author=Kawachi H, Tamura H, Watakabe I, "et al." |title=Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family. |journal=Brain Res. Mol. Brain Res. |volume=72 |issue= 1 |pages= 47–54 |year= 1999 |pmid= 10521598 |doi=
*cite journal | author=Liu S, Kulp SK, Sugimoto Y, "et al." |title=Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents. |journal=Breast Cancer Res. Treat. |volume=71 |issue= 1 |pages= 21–35 |year= 2002 |pmid= 11859871 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liu S, Sugimoto Y, Kulp SK, "et al." |title=Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha. |journal=Anticancer Res. |volume=22 |issue= 6C |pages= 3917–23 |year= 2003 |pmid= 12553013 |doi=
*cite journal | author=Liu S, Sugimoto Y, Sorio C, "et al." |title=Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTPgamma) in human breast cancer cell line MCF-7. |journal=Oncogene |volume=23 |issue= 6 |pages= 1256–62 |year= 2004 |pmid= 14676845 |doi= 10.1038/sj.onc.1207235
*cite journal | author=van Doorn R, Zoutman WH, Dijkman R, "et al." |title=Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. |journal=J. Clin. Oncol. |volume=23 |issue= 17 |pages= 3886–96 |year= 2005 |pmid= 15897551 |doi= 10.1200/JCO.2005.11.353
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes