- ACP1
Acid phosphatase 1, soluble, also known as ACP1, is a human
gene . PBB_Summary
section_title =
summary_text = The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Three transcript variants encoding distinct isoforms have been identified for this gene.cite web | title = Entrez Gene: ACP1 acid phosphatase 1, soluble| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=52| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Junien C, Kaplan JC, Bernheim A, Berger R |title=Regional assignment of red cell acid phosphatase locus to band 2p25. |journal=Hum. Genet. |volume=48 |issue= 1 |pages= 17–21 |year= 1979 |pmid= 457131 |doi=
*cite journal | author=Sensabaugh GF, Golden VL |title=Phenotype dependence in the inhibition of red cell acid phosphatase (ACP) by folates. |journal=Am. J. Hum. Genet. |volume=30 |issue= 5 |pages= 553–60 |year= 1979 |pmid= 736044 |doi=
*cite journal | author=Shekels LL, Smith AJ, Van Etten RL, Bernlohr DA |title=Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase. |journal=Protein Sci. |volume=1 |issue= 6 |pages= 710–21 |year= 1993 |pmid= 1304913 |doi=
*cite journal | author=Wo YY, McCormack AL, Shabanowitz J, "et al." |title=Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase. |journal=J. Biol. Chem. |volume=267 |issue= 15 |pages= 10856–65 |year= 1992 |pmid= 1587862 |doi=
*cite journal | author=Dissing J, Johnsen AH |title=Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles. |journal=Biochim. Biophys. Acta |volume=1121 |issue= 3 |pages= 261–8 |year= 1992 |pmid= 1627603 |doi=
*cite journal | author=Dissing J, Johnsen AH, Sensabaugh GF |title=Human red cell acid phosphatase (ACP1). The amino acid sequence of the two isozymes Bf and Bs encoded by the ACP1*B allele. |journal=J. Biol. Chem. |volume=266 |issue= 31 |pages= 20619–25 |year= 1991 |pmid= 1939112 |doi=
*cite journal | author=Wakita Y, Narahara K, Takahashi Y, "et al." |title=Duplication of 2p25: confirmation of the assignment of soluble acid phosphatase (ACP1) locus to 2p25. |journal=Hum. Genet. |volume=71 |issue= 3 |pages= 259–60 |year= 1986 |pmid= 4065897 |doi=
*cite journal | author=Blake NM, Kirk RL, Barnes KR, Thompson JM |title=Expression of human red cell acid phosphatase activity in placenta and other tissues. |journal=Jinrui Idengaku Zasshi |volume=18 |issue= 1 |pages= 10–23 |year= 1974 |pmid= 4356849 |doi=
*cite journal | author=Sensabaugh GF, Lazaruk KA |title=A TaqI site identifies the *A allele at the ACP1 locus. |journal=Hum. Mol. Genet. |volume=2 |issue= 7 |pages= 1079 |year= 1993 |pmid= 8364553 |doi=
*cite journal | author=Bryson GL, Massa H, Trask BJ, Van Etten RL |title=Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1. |journal=Genomics |volume=30 |issue= 2 |pages= 133–40 |year= 1996 |pmid= 8586411 |doi=
*cite journal | author=Tailor P, Gilman J, Williams S, "et al." |title=Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 5371–4 |year= 1997 |pmid= 9038134 |doi=
*cite journal | author=Stein E, Lane AA, Cerretti DP, "et al." |title=Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. |journal=Genes Dev. |volume=12 |issue= 5 |pages= 667–78 |year= 1998 |pmid= 9499402 |doi=
*cite journal | author=Modesti A, Marzocchini R, Raugei G, "et al." |title=Cloning, expression and characterisation of a new human low Mr phosphotyrosine protein phosphatase originating by alternative splicing. |journal=FEBS Lett. |volume=431 |issue= 1 |pages= 111–5 |year= 1998 |pmid= 9684876 |doi=
*cite journal | author=Zhang M, Stauffacher CV, Lin D, Van Etten RL |title=Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21714–20 |year= 1998 |pmid= 9705307 |doi=
*cite journal | author=Tailor P, Gilman J, Williams S, Mustelin T |title=A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicing. |journal=Eur. J. Biochem. |volume=262 |issue= 2 |pages= 277–82 |year= 1999 |pmid= 10336608 |doi=
*cite journal | author=Huang L, Sankar S, Lin C, "et al." |title=HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 38183–8 |year= 2000 |pmid= 10608891 |doi=
*cite journal | author=Nicolas G, Fournier CM, Galand C, "et al." |title=Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain. |journal=Mol. Cell. Biol. |volume=22 |issue= 10 |pages= 3527–36 |year= 2002 |pmid= 11971983 |doi=
*cite journal | author=Bottini N, Stefanini L, Williams S, "et al." |title=Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24220–4 |year= 2002 |pmid= 11976341 |doi= 10.1074/jbc.M202885200
*cite journal | author=Bottini N, Ammendola M, Gloria-Bottini F |title=ACP1 is associated with allergy. |journal=Allergy |volume=57 |issue= 7 |pages= 651–2 |year= 2002 |pmid= 12100313 |doi=
*cite journal | author=Kikawa KD, Vidale DR, Van Etten RL, Kinch MS |title=Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39274–9 |year= 2002 |pmid= 12167657 |doi= 10.1074/jbc.M207127200PBB_Controls
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