RAPGEF1

Rap guanine nucleotide exchange factor (GEF) 1, also known as RAPGEF1, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a human guanine nucleotide releasing protein for Ras protein. It belongs to the adaptor-type Src homology (SH)2-containing molecules. Src homology 2 domains are globular protein modules present in a large variety of functionally distinct proteins. They mediate binding events that control the activity and localization of many proteins involved in the transmission of signals from the cell surface to the nucleus. The mRNAs of these proteins are expressed ubiquitously in human adult and fetal tissues. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.cite web | title = Entrez Gene: RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2889| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pessin JE, Okada S |title=Insulin and EGF receptors integrate the Ras and Rap signaling pathways. |journal=Endocr. J. |volume=46 Suppl |issue= |pages= S11–6 |year= 2002 |pmid= 12054111 |doi=
*cite journal | author=Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW |title=Ras and relatives--job sharing and networking keep an old family together. |journal=Exp. Hematol. |volume=30 |issue= 10 |pages= 1089–106 |year= 2002 |pmid= 12384139 |doi=
*cite journal | author=Tanaka S, Morishita T, Hashimoto Y, "et al." |title=C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 3443–7 |year= 1994 |pmid= 7512734 |doi=
*cite journal | author=Knudsen BS, Feller SM, Hanafusa H |title=Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk. |journal=J. Biol. Chem. |volume=269 |issue= 52 |pages= 32781–7 |year= 1995 |pmid= 7806500 |doi=
*cite journal | author=Takai S, Tanaka M, Sugimura H, "et al." |title=Mapping of the human C3G gene coding a guanine nucleotide releasing protein for Ras family to 9q34.3 by fluorescence in situ hybridization. |journal=Hum. Genet. |volume=94 |issue= 5 |pages= 549–50 |year= 1994 |pmid= 7959692 |doi=
*cite journal | author=Gotoh T, Hattori S, Nakamura S, "et al." |title=Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. |journal=Mol. Cell. Biol. |volume=15 |issue= 12 |pages= 6746–53 |year= 1996 |pmid= 8524240 |doi=
*cite journal | author=Smit L, van der Horst G, Borst J |title=Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8564–9 |year= 1996 |pmid= 8621483 |doi=
*cite journal | author=Matsuda M, Ota S, Tanimura R, "et al." |title=Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14468–72 |year= 1996 |pmid= 8662907 |doi=
*cite journal | author=Uemura N, Salgia R, Li JL, "et al." |title=The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins. |journal=Leukemia |volume=11 |issue= 3 |pages= 376–85 |year= 1997 |pmid= 9067577 |doi=
*cite journal | author=Husson H, Mograbi B, Schmid-Antomarchi H, "et al." |title=CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2. |journal=Oncogene |volume=14 |issue= 19 |pages= 2331–8 |year= 1997 |pmid= 9178909 |doi= 10.1038/sj.onc.1201074
*cite journal | author=Chin H, Saito T, Arai A, "et al." |title=Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 412–7 |year= 1997 |pmid= 9344843 |doi= 10.1006/bbrc.1997.7480
*cite journal | author=Ahmad S, Alsayed YM, Druker BJ, Platanias LC |title=The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 29991–4 |year= 1997 |pmid= 9374471 |doi=
*cite journal | author=Guerrero C, Fernandez-Medarde A, Rojas JM, "et al." |title=Transformation suppressor activity of C3G is independent of its CDC25-homology domain. |journal=Oncogene |volume=16 |issue= 5 |pages= 613–24 |year= 1998 |pmid= 9482107 |doi= 10.1038/sj.onc.1201569
*cite journal | author=Ohashi Y, Tachibana K, Kamiguchi K, "et al." |title=T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G. |journal=J. Biol. Chem. |volume=273 |issue= 11 |pages= 6446–51 |year= 1998 |pmid= 9497377 |doi=
*cite journal | author=Astier A, Manié SN, Law SF, "et al." |title=Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells. |journal=Leuk. Lymphoma |volume=28 |issue= 1-2 |pages= 65–72 |year= 1998 |pmid= 9498705 |doi=
*cite journal | author=Yokote K, Hellman U, Ekman S, "et al." |title=Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins. |journal=Oncogene |volume=16 |issue= 10 |pages= 1229–39 |year= 1998 |pmid= 9546424 |doi= 10.1038/sj.onc.1201641
*cite journal | author=Kirsch KH, Georgescu MM, Hanafusa H |title=Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25673–9 |year= 1998 |pmid= 9748234 |doi=
*cite journal | author=Ichiba T, Hashimoto Y, Nakaya M, "et al." |title=Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14376–81 |year= 1999 |pmid= 10318861 |doi=
*cite journal | author=Nosaka Y, Arai A, Miyasaka N, Miura O |title=CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30154–62 |year= 1999 |pmid= 10514505 |doi=
*cite journal | author=Uemura N, Griffin JD |title=The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37525–32 |year= 2000 |pmid= 10608804 |doi=

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