PTPRU

Protein tyrosine phosphatase, receptor type, U, also known as PTPRU, is a human gene.cite web | title = Entrez Gene: PTPRU protein tyrosine phosphatase, receptor type, U| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10076| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Three alternatively spliced transcript variants, which encode distinct proteins, have been reported.cite web | title = Entrez Gene: PTPRU protein tyrosine phosphatase, receptor type, U| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10076| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wang H, Lian Z, Lerch MM, "et al." |title=Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family. |journal=Oncogene |volume=12 |issue= 12 |pages= 2555–62 |year= 1996 |pmid= 8700514 |doi=
*cite journal | author=Crossland S, Smith PD, Crompton MR |title=Molecular cloning and characterization of PTP pi, a novel receptor-like protein-tyrosine phosphatase. |journal=Biochem. J. |volume=319 ( Pt 1) |issue= |pages= 249–54 |year= 1996 |pmid= 8870675 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Wang B, Kishihara K, Zhang D, "et al." |title=Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells. |journal=Biochem. Biophys. Res. Commun. |volume=231 |issue= 1 |pages= 77–81 |year= 1997 |pmid= 9070223 |doi= 10.1006/bbrc.1997.6004
*cite journal | author=Lin BZ, Pilch PF, Kandror KV |title=Sortilin is a major protein component of Glut4-containing vesicles. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24145–7 |year= 1997 |pmid= 9305862 |doi=
*cite journal | author=Avraham S, London R, Tulloch GA, "et al." |title=Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells. |journal=Gene |volume=204 |issue= 1-2 |pages= 5–16 |year= 1998 |pmid= 9434160 |doi=
*cite journal | author=Serra-Pagès C, Medley QG, Tang M, "et al." |title=Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15611–20 |year= 1998 |pmid= 9624153 |doi=
*cite journal | author=Luo Y, Denker BM |title=Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 10685–8 |year= 1999 |pmid= 10196137 |doi=
*cite journal | author=Wang B, Kishihara K, Zhang D, "et al." |title=Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells. |journal=Biochim. Biophys. Acta |volume=1450 |issue= 3 |pages= 331–40 |year= 1999 |pmid= 10395944 |doi=
*cite journal | author=Taniguchi Y, London R, Schinkmann K, "et al." |title=The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor. |journal=Blood |volume=94 |issue= 2 |pages= 539–49 |year= 1999 |pmid= 10397721 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yan HX, He YQ, Dong H, "et al." |title=Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin. |journal=Biochemistry |volume=41 |issue= 52 |pages= 15854–60 |year= 2003 |pmid= 12501215 |doi=
*cite journal | author=Amoui M, Baylink DJ, Tillman JB, Lau KH |title=Expression of a structurally unique osteoclastic protein-tyrosine phosphatase is driven by an alternative intronic, cell type-specific promoter. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44273–80 |year= 2004 |pmid= 12949066 |doi= 10.1074/jbc.M303933200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Willard FS, McCudden CR, Siderovski DP |title=G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2). |journal=Cell. Signal. |volume=18 |issue= 8 |pages= 1226–34 |year= 2006 |pmid= 16298104 |doi= 10.1016/j.cellsig.2005.10.003
*cite journal | author=Hirakawa M, Tsuruya K, Yotsueda H, "et al." |title=Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis. |journal=Life Sci. |volume=79 |issue= 8 |pages= 757–63 |year= 2006 |pmid= 16564554 |doi= 10.1016/j.lfs.2006.02.031
*cite journal | author=Yan HX, Yang W, Zhang R, "et al." |title=Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion. |journal=J. Biol. Chem. |volume=281 |issue= 22 |pages= 15423–33 |year= 2006 |pmid= 16574648 |doi= 10.1074/jbc.M602607200

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