- PTPN4
Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), also known as PTPN4, is a human
gene .cite web | title = Entrez Gene: PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5775| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.cite web | title = Entrez Gene: PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5775| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Gu MX, York JD, Warshawsky I, Majerus PW |title=Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 13 |pages= 5867–71 |year= 1991 |pmid= 1648233 |doi=
*cite journal | author=Gu M, Majerus PW |title=The properties of the protein tyrosine phosphatase PTPMEG. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27751–9 |year= 1996 |pmid= 8910369 |doi=
*cite journal | author=Gu M, Meng K, Majerus PW |title=The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 23 |pages= 12980–5 |year= 1996 |pmid= 8917530 |doi=
*cite journal | author=Hironaka K, Umemori H, Tezuka T, "et al." |title=The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits. |journal=J. Biol. Chem. |volume=275 |issue= 21 |pages= 16167–73 |year= 2000 |pmid= 10748123 |doi= 10.1074/jbc.M909302199
*cite journal | author=Gjörloff-Wingren A, Saxena M, Han S, "et al." |title=Subcellular localization of intracellular protein tyrosine phosphatases in T cells. |journal=Eur. J. Immunol. |volume=30 |issue= 8 |pages= 2412–21 |year= 2000 |pmid= 10940933 |doi=
*cite journal | author=Park KW, Lee EJ, Lee S, "et al." |title=Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG. |journal=Gene |volume=257 |issue= 1 |pages= 45–55 |year= 2001 |pmid= 11054567 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029PBB_Controls
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