- PTK2
PTK2 protein tyrosine kinase 2, also known as PTK2, is a human
gene .PBB_Summary
section_title =
summary_text = This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. [cite web | title = Entrez Gene: PTK2 PTK2 protein tyrosine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5747| accessdate = ]ee also
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Tyrosine kinase References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Iwata S, Ohashi Y, Kamiguchi K, Morimoto C |title=Beta 1-integrin-mediated cell signaling in T lymphocytes. |journal=J. Dermatol. Sci. |volume=23 |issue= 2 |pages= 75–86 |year= 2000 |pmid= 10808124 |doi=
*cite journal | author=Schaller MD |title=Biochemical signals and biological responses elicited by the focal adhesion kinase. |journal=Biochim. Biophys. Acta |volume=1540 |issue= 1 |pages= 1–21 |year= 2001 |pmid= 11476890 |doi=
*cite journal | author=Panetti TS |title=Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration. |journal=Front. Biosci. |volume=7 |issue= |pages= d143–50 |year= 2002 |pmid= 11779709 |doi=
*cite journal | author=Hauck CR, Hsia DA, Schlaepfer DD |title=The focal adhesion kinase--a regulator of cell migration and invasion. |journal=IUBMB Life |volume=53 |issue= 2 |pages= 115–9 |year= 2003 |pmid= 12049193 |doi=
*cite journal | author=Hanks SK, Ryzhova L, Shin NY, Brábek J |title=Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. |journal=Front. Biosci. |volume=8 |issue= |pages= d982–96 |year= 2004 |pmid= 12700132 |doi=
*cite journal | author=Gabarra-Niecko V, Schaller MD, Dunty JM |title=FAK regulates biological processes important for the pathogenesis of cancer. |journal=Cancer Metastasis Rev. |volume=22 |issue= 4 |pages= 359–74 |year= 2004 |pmid= 12884911 |doi=PBB_Controls
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