PTPN9

Protein tyrosine phosphatase, non-receptor type 9, also known as PTPN9, is a human gene.cite web | title = Entrez Gene: PTPN9 protein tyrosine phosphatase, non-receptor type 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5780| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis.cite web | title = Entrez Gene: PTPN9 protein tyrosine phosphatase, non-receptor type 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5780| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gu M, Warshawsky I, Majerus PW |title=Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 7 |pages= 2980–4 |year= 1992 |pmid= 1557404 |doi=
*cite journal | author=Kruger JM, Fukushima T, Cherepanov V, "et al." |title=Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides. |journal=J. Biol. Chem. |volume=277 |issue= 4 |pages= 2620–8 |year= 2002 |pmid= 11711529 |doi= 10.1074/jbc.M104550200
*cite journal | author=Qi Y, Zhao R, Cao H, "et al." |title=Purification and characterization of protein tyrosine phosphatase PTP-MEG2. |journal=J. Cell. Biochem. |volume=86 |issue= 1 |pages= 79–89 |year= 2002 |pmid= 12112018 |doi= 10.1002/jcb.10195
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Pasquali C, Curchod ML, Wälchli S, "et al." |title=Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor. |journal=Mol. Endocrinol. |volume=17 |issue= 11 |pages= 2228–39 |year= 2004 |pmid= 12907755 |doi= 10.1210/me.2003-0011
*cite journal | author=Xu MJ, Sui X, Zhao R, "et al." |title=PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells. |journal=Blood |volume=102 |issue= 13 |pages= 4354–60 |year= 2004 |pmid= 12920026 |doi= 10.1182/blood-2003-04-1308
*cite journal | author=Huynh H, Wang X, Li W, "et al." |title=Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6661–71 |year= 2004 |pmid= 14662869 |doi=
*cite journal | author=Huynh H, Bottini N, Williams S, "et al." |title=Control of vesicle fusion by a tyrosine phosphatase. |journal=Nat. Cell Biol. |volume=6 |issue= 9 |pages= 831–9 |year= 2004 |pmid= 15322554 |doi= 10.1038/ncb1164
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Cho CY, Koo SH, Wang Y, "et al." |title=Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. |journal=Cell Metab. |volume=3 |issue= 5 |pages= 367–78 |year= 2007 |pmid= 16679294 |doi= 10.1016/j.cmet.2006.03.006
*cite journal | author=Saito K, Williams S, Bulankina A, "et al." |title=Association of protein-tyrosine phosphatase MEG2 via its Sec14p homology domain with vesicle-trafficking proteins. |journal=J. Biol. Chem. |volume=282 |issue= 20 |pages= 15170–8 |year= 2007 |pmid= 17387180 |doi= 10.1074/jbc.M608682200

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