PTPN18

Protein tyrosine phosphatase, non-receptor type 18 (brain-derived), also known as PTPN18, is a human gene.cite web | title = Entrez Gene: PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26469| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The bilogical function of this PTP has not yet been determined.cite web | title = Entrez Gene: PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26469| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kim YW, Wang H, Sures I, "et al." |title=Characterization of the PEST family protein tyrosine phosphatase BDP1. |journal=Oncogene |volume=13 |issue= 10 |pages= 2275–9 |year= 1997 |pmid= 8950995 |doi=
*cite journal | author=Spencer S, Dowbenko D, Cheng J, "et al." |title=PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase. |journal=J. Cell Biol. |volume=138 |issue= 4 |pages= 845–60 |year= 1997 |pmid= 9265651 |doi=
*cite journal | author=Dowbenko D, Spencer S, Quan C, Lasky LA |title=Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein. |journal=J. Biol. Chem. |volume=273 |issue= 2 |pages= 989–96 |year= 1998 |pmid= 9422760 |doi=
*cite journal | author=Wu Y, Dowbenko D, Lasky LA |title=PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30487–96 |year= 1998 |pmid= 9804817 |doi=
*cite journal | author=Wang B, Lemay S, Tsai S, Veillette A |title=SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1077–88 |year= 2001 |pmid= 11158295 |doi= 10.1128/MCB.21.4.1077-1088.2001
*cite journal | author=Cong F, Spencer S, Côté JF, "et al." |title=Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation. |journal=Mol. Cell |volume=6 |issue= 6 |pages= 1413–23 |year= 2001 |pmid= 11163214 |doi=
*cite journal | author=Wise CA, Gillum JD, Seidman CE, "et al." |title=Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder. |journal=Hum. Mol. Genet. |volume=11 |issue= 8 |pages= 961–9 |year= 2003 |pmid= 11971877 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shiota M, Tanihiro T, Nakagawa Y, "et al." |title=Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone. |journal=Mol. Endocrinol. |volume=17 |issue= 4 |pages= 534–49 |year= 2004 |pmid= 12554790 |doi= 10.1210/me.2002-0187
*cite journal | author=Gensler M, Buschbeck M, Ullrich A |title=Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12110–6 |year= 2004 |pmid= 14660651 |doi= 10.1074/jbc.M309527200
*cite journal | author=Aoki N, Ueno S, Mano H, "et al." |title=Mutual regulation of protein-tyrosine phosphatase 20 and protein-tyrosine kinase Tec activities by tyrosine phosphorylation and dephosphorylation. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10765–75 |year= 2004 |pmid= 14679216 |doi= 10.1074/jbc.M310401200
*cite journal | author=Blanchetot C, Chagnon M, Dubé N, "et al." |title=Substrate-trapping techniques in the identification of cellular PTP targets. |journal=Methods |volume=35 |issue= 1 |pages= 44–53 |year= 2005 |pmid= 15588985 |doi= 10.1016/j.ymeth.2004.07.007
*cite journal | author=Zhang Y, Wolf-Yadlin A, Ross PL, "et al." |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200
*cite journal | author=Tao WA, Wollscheid B, O'Brien R, "et al." |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591–8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776
*cite journal | author=Gandhi TK, Chandran S, Peri S, "et al." |title=A bioinformatics analysis of protein tyrosine phosphatases in humans. |journal=DNA Res. |volume=12 |issue= 2 |pages= 79–89 |year= 2007 |pmid= 16303740 |doi= 10.1093/dnares/12.2.79

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