PTPRJ

Protein tyrosine phosphatase, receptor type, J, also known as PTPRJ, is a human gene.cite web | title = Entrez Gene: PTPRJ protein tyrosine phosphatase, receptor type, J| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5795| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.cite web | title = Entrez Gene: PTPRJ protein tyrosine phosphatase, receptor type, J| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5795| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Harrod TR, Justement LB |title=Evaluating function of transmembrane protein tyrosine phosphatase CD148 in lymphocyte biology. |journal=Immunol. Res. |volume=26 |issue= 1-3 |pages= 153–66 |year= 2003 |pmid= 12403354 |doi=
*cite journal | author=Ostman A, Yang Q, Tonks NK |title=Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 21 |pages= 9680–4 |year= 1994 |pmid= 7937872 |doi=
*cite journal | author=Honda H, Inazawa J, Nishida J, "et al." |title=Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta. |journal=Blood |volume=84 |issue= 12 |pages= 4186–94 |year= 1995 |pmid= 7994032 |doi=
*cite journal | author=Jallal B, Mossie K, Vasiloudis G, "et al." |title=The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 12158–63 |year= 1997 |pmid= 9115287 |doi=
*cite journal | author=de la Fuente-García MA, Nicolás JM, Freed JH, "et al." |title=CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes. |journal=Blood |volume=91 |issue= 8 |pages= 2800–9 |year= 1998 |pmid= 9531590 |doi=
*cite journal | author=Tangye SG, Phillips JH, Lanier LL, "et al." |title=CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation. |journal=J. Immunol. |volume=161 |issue= 7 |pages= 3249–55 |year= 1998 |pmid= 9759839 |doi=
*cite journal | author=Gross S, Knebel A, Tenev T, "et al." |title=Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction. |journal=J. Biol. Chem. |volume=274 |issue= 37 |pages= 26378–86 |year= 1999 |pmid= 10473595 |doi=
*cite journal | author=Autschbach F, Palou E, Mechtersheimer G, "et al." |title=Expression of the membrane protein tyrosine phosphatase CD148 in human tissues. |journal=Tissue Antigens |volume=54 |issue= 5 |pages= 485–98 |year= 2000 |pmid= 10599888 |doi=
*cite journal | author=Billard C, Delaire S, Raffoux E, "et al." |title=Switch in the protein tyrosine phosphatase associated with human CD100 semaphorin at terminal B-cell differentiation stage. |journal=Blood |volume=95 |issue= 3 |pages= 965–72 |year= 2000 |pmid= 10648410 |doi=
*cite journal | author=Kovalenko M, Denner K, Sandström J, "et al." |title=Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1. |journal=J. Biol. Chem. |volume=275 |issue= 21 |pages= 16219–26 |year= 2000 |pmid= 10821867 |doi=
*cite journal | author=del Pozo V, Pirotto F, Cárdaba B, "et al." |title=Expression on human eosinophils of CD148: a membrane tyrosine phosphatase. Implications in the effector function of eosinophils. |journal=J. Leukoc. Biol. |volume=68 |issue= 1 |pages= 31–7 |year= 2000 |pmid= 10914487 |doi=
*cite journal | author=Baker JE, Majeti R, Tangye SG, Weiss A |title=Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. |journal=Mol. Cell. Biol. |volume=21 |issue= 7 |pages= 2393–403 |year= 2001 |pmid= 11259588 |doi= 10.1128/MCB.21.7.2393-2403.2001
*cite journal | author=Persson C, Engström U, Mowbray SL, Ostman A |title=Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1. |journal=FEBS Lett. |volume=517 |issue= 1-3 |pages= 27–31 |year= 2002 |pmid= 12062403 |doi=
*cite journal | author=Ruivenkamp CA, van Wezel T, Zanon C, "et al." |title=Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 295–300 |year= 2002 |pmid= 12089527 |doi= 10.1038/ng903
*cite journal | author=Holsinger LJ, Ward K, Duffield B, "et al." |title=The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn). |journal=Oncogene |volume=21 |issue= 46 |pages= 7067–76 |year= 2002 |pmid= 12370829 |doi= 10.1038/sj.onc.1205858
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Dong HY, Shahsafaei A, Dorfman DM |title=CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells. |journal=Leuk. Lymphoma |volume=43 |issue= 9 |pages= 1855–8 |year= 2003 |pmid= 12685844 |doi=
*cite journal | author=Kellie S, Craggs G, Bird IN, Jones GE |title=The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation. |journal=J. Cell. Sci. |volume=117 |issue= Pt 4 |pages= 609–18 |year= 2004 |pmid= 14709717 |doi= 10.1242/jcs.00879
*cite journal | author=Massa A, Barbieri F, Aiello C, "et al." |title=The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29004–12 |year= 2004 |pmid= 15123617 |doi= 10.1074/jbc.M403573200

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