CTNND1

Catenin (cadherin-associated protein), delta 1
Rendering based on PDB 3L6X.
Available structures PDB 3L6X, 3L6Y
Identifiers
Symbols	CTNND1; CAS; CTNND; KIAA0384; P120CAS; P120CTN; p120; p120(CAS); p120(CTN)
External IDs	OMIM: 601045 MGI: 105100 HomoloGene: 1017 GeneCards: CTNND1 Gene
Gene Ontology Molecular function • receptor binding • protein binding • protein phosphatase binding • protein domain specific binding • RPTP-like protein binding • cadherin binding Cellular component • membrane fraction • nucleus • cytoplasm • cytosol • plasma membrane • plasma membrane • plasma membrane • cell-cell junction • cell-cell adherens junction • lamellipodium • midbody Biological process • morphogenesis of a polarized epithelium • regulation of transcription, DNA-dependent • cell adhesion • salivary gland morphogenesis • Wnt receptor signaling pathway • cell-cell adhesion • keratinocyte differentiation • cell junction assembly • adherens junction organization • cell-cell junction organization • epithelial cell differentiation involved in salivary gland development • negative regulation of canonical Wnt receptor signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1500	12388
Ensembl	ENSG00000198561	ENSMUSG00000034101
UniProt	O60716	Q3TSU9
RefSeq (mRNA)	NM_001085458.1	NM_007615
RefSeq (protein)	NP_001078927.1	NP_031641
Location (UCSC)	Chr 11: 57.52 – 57.59 Mb	Chr 2: 84.44 – 84.49 Mb
PubMed search	[1]	[2]

Catenin delta-1 is a protein that in humans is encoded by the CTNND1 gene.^[1]

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and althernative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.^[2]

Interactions

CTNND1 has been shown to interact with Beta-catenin,^[3][4] FYN,^[5][6] Collagen, type XVII, alpha 1,^[7] PTPN6,^[8] YES1,^[6] PTPRJ,^[9] VE-cadherin,^[10][11] MUC1,^[12] CDH1,^{[3][6][13][14][15][16][17][18]} CDH2,^[19][20] PTPRM,^[21] Cortactin,^[5] Nephrin,^[22] ZBTB33^[23] and PSEN1.^[24]

See also

• Delta catenin
• Catenin
• CTNND2

References

1. ^ Reynolds AB, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro DN, Wu J, Daniel JM (Oct 1996). "The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)". Genomics 31 (1): 127–9. doi:10.1006/geno.1996.0020. PMID 8808291. 
2. ^ "Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1500. 
3. ^ ^{a b} Hazan, R B; Norton L (Apr. 1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. (UNITED STATES) 273 (15): 9078–84. doi:10.1074/jbc.273.15.9078. ISSN 0021-9258. PMID 9535896. 
4. ^ Kucerová, D; Sloncová E, Tuhácková Z, Vojtechová M, Sovová V (Dec. 2001). "Expression and interaction of different catenins in colorectal carcinoma cells". Int. J. Mol. Med. (Greece) 8 (6): 695–8. ISSN 1107-3756. PMID 11712088. 
5. ^ ^{a b} Martinez, Maria Cruz; Ochiishi Tomoyo, Majewski Michael, Kosik Kenneth S (Jul. 2003). "Dual regulation of neuronal morphogenesis by a δ-catenin–cortactin complex and Rho". J. Cell Biol. (United States) 162 (1): 99–111. doi:10.1083/jcb.200211025. ISSN 0021-9525. PMC 2172717. PMID 12835311. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172717. 
6. ^ ^{a b c} Piedra, Jose; Miravet Susana, Castaño Julio, Pálmer Héctor G, Heisterkamp Nora, García de Herreros Antonio, Duñach Mireia (Apr. 2003). "p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction". Mol. Cell. Biol. (United States) 23 (7): 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. ISSN 0270-7306. PMC 150740. PMID 12640114. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=150740. 
7. ^ Aho, S; Rothenberger K, Uitto J (Jun. 1999). "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen". J. Cell. Biochem. (UNITED STATES) 73 (3): 390–9. doi:10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1. ISSN 0730-2312. PMID 10321838. 
8. ^ Keilhack, H; Hellman U, van Hengel J, van Roy F, Godovac-Zimmermann J, Böhmer F D (Aug. 2000). "The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin". J. Biol. Chem. (UNITED STATES) 275 (34): 26376–84. doi:10.1074/jbc.M001315200. ISSN 0021-9258. PMID 10835420. 
9. ^ Holsinger, Leslie J; Ward Kevin, Duffield Bill, Zachwieja Joseph, Jallal Bahija (Oct. 2002). "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene (England) 21 (46): 7067–76. doi:10.1038/sj.onc.1205858. ISSN 0950-9232. PMID 12370829. 
10. ^ Ferber, Andres; Yaen Christopher, Sarmiento Edna, Martinez Jose (Mar. 2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. (United States) 274 (1): 35–44. doi:10.1006/excr.2001.5436. ISSN 0014-4827. PMID 11855855. 
11. ^ Lampugnani, M G; Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (Sep. 1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell. Sci. (ENGLAND) 110 ( Pt 17): 2065–77. ISSN 0021-9533. PMID 9378757. 
12. ^ Li, Y; Kufe D (Feb. 2001). "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)". Biochem. Biophys. Res. Commun. (United States) 281 (2): 440–3. doi:10.1006/bbrc.2001.4383. ISSN 0006-291X. PMID 11181067. 
13. ^ Daniel, J M; Reynolds A B (Sep. 1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. (UNITED STATES) 15 (9): 4819–24. ISSN 0270-7306. PMC 230726. PMID 7651399. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230726. 
14. ^ Ireton, Renee C; Davis Michael A, van Hengel Jolanda, Mariner Deborah J, Barnes Kirk, Thoreson Molly A, Anastasiadis Panos Z, Matrisian Linsey, Bundy Linda M, Sealy Linda, Gilbert Barbara, van Roy Frans, Reynolds Albert B (Nov. 2002). "A novel role for p120 catenin in E-cadherin function". J. Cell Biol. (United States) 159 (3): 465–76. doi:10.1083/jcb.200205115. ISSN 0021-9525. PMC 2173073. PMID 12427869. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173073. 
15. ^ Kinch, M S; Clark G J, Der C J, Burridge K (Jul. 1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. (UNITED STATES) 130 (2): 461–71. doi:10.1083/jcb.130.2.461. ISSN 0021-9525. PMC 2199929. PMID 7542250. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199929. 
16. ^ Bonné, Stefan; Gilbert Barbara, Hatzfeld Mechthild, Chen Xinyu, Green Kathleen J, van Roy Frans (Apr. 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. (United States) 161 (2): 403–16. doi:10.1083/jcb.200303036. ISSN 0021-9525. PMC 2172904. PMID 12707304. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172904. 
17. ^ Shibamoto, S; Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson K R, Wheelock M J, Matsuyoshi N, Takeichi M (Mar. 1995). "Association of p120, a tyrosine kinase substrate, with E- cadherin/catenin complexes". J. Cell Biol. (UNITED STATES) 128 (5): 949–57. doi:10.1083/jcb.128.5.949. ISSN 0021-9525. PMC 2120395. PMID 7876318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120395. 
18. ^ Ohkubo, T; Ozawa M (Jul. 1999). "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity". J. Biol. Chem. (UNITED STATES) 274 (30): 21409–15. doi:10.1074/jbc.274.30.21409. ISSN 0021-9258. PMID 10409703. 
19. ^ Straub, Beate K; Boda Judit, Kuhn Caecilia, Schnoelzer Martina, Korf Ulrike, Kempf Tore, Spring Herbert, Hatzfeld Mechthild, Franke Werner W (Dec. 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell. Sci. (England) 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. ISSN 0021-9533. PMID 14625392. 
20. ^ Wahl, James K; Kim Young J, Cullen Janet M, Johnson Keith R, Wheelock Margaret J (May. 2003). "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. (United States) 278 (19): 17269–76. doi:10.1074/jbc.M211452200. ISSN 0021-9258. PMID 12604612. 
21. ^ Zondag, G C; Reynolds A B, Moolenaar W H (Apr. 2000). "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)". J. Biol. Chem. (UNITED STATES) 275 (15): 11264–9. doi:10.1074/jbc.275.15.11264. ISSN 0021-9258. PMID 10753936. 
22. ^ Lehtonen, Sanna; Lehtonen Eero, Kudlicka Krystyna, Holthöfer Harry, Farquhar Marilyn G (Sep. 2004). "Nephrin Forms a Complex with Adherens Junction Proteins and CASK in Podocytes and in Madin-Darby Canine Kidney Cells Expressing Nephrin". Am. J. Pathol. (United States) 165 (3): 923–36. doi:10.1016/S0002-9440(10)63354-8. ISSN 0002-9440. PMC 1618613. PMID 15331416. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1618613. 
23. ^ Daniel, J M; Reynolds A B (May. 1999). "The Catenin p120ctn Interacts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor". Mol. Cell. Biol. (UNITED STATES) 19 (5): 3614–23. ISSN 0270-7306. PMC 84161. PMID 10207085. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84161. 
24. ^ Tanahashi, H; Tabira T (Feb. 1999). "Isolation of human delta-catenin and its binding specificity with presenilin 1". Neuroreport (ENGLAND) 10 (3): 563–8. doi:10.1097/00001756-199902250-00022. ISSN 0959-4965. PMID 10208590. 

Further reading

• Wijnhoven BP, Dinjens WN, Pignatelli M (2000). "E-cadherin-catenin cell-cell adhesion complex and human cancer". The British journal of surgery 87 (8): 992–1005. doi:10.1046/j.1365-2168.2000.01513.x. PMID 10931041. 
• Thoreson MA, Reynolds AB (2003). "Altered expression of the catenin p120 in human cancer: implications for tumor progression". Differentiation 70 (9–10): 583–9. doi:10.1046/j.1432-0436.2002.700911.x. PMID 12492499. 
• Reynolds AB, Carnahan RH (2005). "Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer". Semin. Cell Dev. Biol. 15 (6): 657–63. doi:10.1016/j.semcdb.2004.09.003. PMID 15561585. 
• Keil R, Wolf A, Hüttelmaier S, Hatzfeld M (2007). "Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin". Cell Cycle 6 (2): 122–7. doi:10.4161/cc.6.2.3741. PMID 17264675. 
• Kinch MS, Clark GJ, Der CJ, Burridge K (1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. 130 (2): 461–71. doi:10.1083/jcb.130.2.461. PMC 2199929. PMID 7542250. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199929. 
• Daniel JM, Reynolds AB (1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. 15 (9): 4819–24. PMC 230726. PMID 7651399. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230726. 
• Shibamoto S, Hayakawa M, Takeuchi K et al. (1995). "Association of p120, a tyrosine kinase substrate, with E- cadherin/catenin complexes". J. Cell Biol. 128 (5): 949–57. doi:10.1083/jcb.128.5.949. PMC 2120395. PMID 7876318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120395. 
• Reynolds AB, Daniel JM, Mo YY et al. (1996). "The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts". Exp. Cell Res. 225 (2): 328–37. doi:10.1006/excr.1996.0183. PMID 8660921. 
• Nagase T, Ishikawa K, Nakajima D et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841. 
• Lampugnani MG, Corada M, Andriopoulou P et al. (1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell. Sci. 110 ( Pt 17): 2065–77. PMID 9378757. 
• Hazan RB, Norton L (1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. 273 (15): 9078–84. doi:10.1074/jbc.273.15.9078. PMID 9535896. 
• Keirsebilck A, Bonné S, Staes K et al. (1998). "Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms". Genomics 50 (2): 129–46. doi:10.1006/geno.1998.5325. PMID 9653641. 
• Bauer A, Lickert H, Kemler R, Stappert J (1998). "Modification of the E-cadherin-catenin complex in mitotic Madin-Darby canine kidney epithelial cells". J. Biol. Chem. 273 (43): 28314–21. doi:10.1074/jbc.273.43.28314. PMID 9774455. 
• Daniel JM, Reynolds AB (1999). "The Catenin p120ctn Interacts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor". Mol. Cell. Biol. 19 (5): 3614–23. PMC 84161. PMID 10207085. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84161. 
• Aono S, Nakagawa S, Reynolds AB, Takeichi M (1999). "p120ctn Acts as an Inhibitory Regulator of Cadherin Function in Colon Carcinoma Cells". J. Cell Biol. 145 (3): 551–62. doi:10.1083/jcb.145.3.551. PMC 2185070. PMID 10225956. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2185070. 
• Aho S, Rothenberger K, Uitto J (1999). "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen". J. Cell. Biochem. 73 (3): 390–9. doi:10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1. PMID 10321838. 
• van Hengel J, Vanhoenacker P, Staes K, van Roy F (1999). "Nuclear localization of the p120ctn Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression". Proc. Natl. Acad. Sci. U.S.A. 96 (14): 7980–5. doi:10.1073/pnas.96.14.7980. PMC 22173. PMID 10393933. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22173. 
• Ohkubo T, Ozawa M (1999). "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity". J. Biol. Chem. 274 (30): 21409–15. doi:10.1074/jbc.274.30.21409. PMID 10409703. 
• Thoreson MA, Anastasiadis PZ, Daniel JM et al. (2000). "Selective Uncoupling of P120ctn from E-Cadherin Disrupts Strong Adhesion". J. Cell Biol. 148 (1): 189–202. doi:10.1083/jcb.148.1.189. PMC 2156209. PMID 10629228. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2156209.