PTPN6

Protein tyrosine phosphatase, non-receptor type 6, also known as PTPN6, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.cite web | title = Entrez Gene: PTPN6 protein tyrosine phosphatase, non-receptor type 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5777| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Blasioli J, Goodnow CC |title=Lyn/CD22/SHP-1 and their importance in autoimmunity. |journal=Curr. Dir. Autoimmun. |volume=5 |issue= |pages= 151–60 |year= 2002 |pmid= 11826756 |doi=10.1159/000060551
*cite journal | author=Tortorella C, Simone O, Piazzolla G, "et al." |title=Age-related impairment of GM-CSF-induced signalling in neutrophils: role of SHP-1 and SOCS proteins. |journal=Ageing Res. Rev. |volume=6 |issue= 2 |pages= 81–93 |year= 2007 |pmid= 17142110 |doi= 10.1016/j.arr.2006.10.001
*cite journal | author=Plutzky J, Neel BG, Rosenberg RD, "et al." |title=Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6). |journal=Genomics |volume=13 |issue= 3 |pages= 869–72 |year= 1992 |pmid= 1639416 |doi=10.1016/0888-7543(92)90172-O
*cite journal | author=Shen SH, Bastien L, Posner BI, Chrétien P |title=A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. |journal=Nature |volume=352 |issue= 6337 |pages= 736–9 |year= 1991 |pmid= 1652101 |doi= 10.1038/352736a0
*cite journal | author=Yi TL, Cleveland JL, Ihle JN |title=Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. |journal=Mol. Cell. Biol. |volume=12 |issue= 2 |pages= 836–46 |year= 1992 |pmid= 1732748 |doi=
*cite journal | author=Plutzky J, Neel BG, Rosenberg RD |title=Isolation of a src homology 2-containing tyrosine phosphatase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 3 |pages= 1123–7 |year= 1992 |pmid= 1736296 |doi=10.1073/pnas.89.3.1123
*cite journal | author=Uchida T, Matozaki T, Noguchi T, "et al." |title=Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 12220–8 |year= 1994 |pmid= 7512963 |doi=
*cite journal | author=Bouchard P, Zhao Z, Banville D, "et al." |title=Phosphorylation and identification of a major tyrosine phosphorylation site in protein tyrosine phosphatase 1C. |journal=J. Biol. Chem. |volume=269 |issue= 30 |pages= 19585–9 |year= 1994 |pmid= 7518460 |doi=
*cite journal | author=Pani G, Kozlowski M, Cambier JC, "et al." |title=Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. |journal=J. Exp. Med. |volume=181 |issue= 6 |pages= 2077–84 |year= 1995 |pmid= 7539038 |doi=10.1084/jem.181.6.2077
*cite journal | author=Arnold SF, Obourn JD, Jaffe H, Notides AC |title=Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro. |journal=Mol. Endocrinol. |volume=9 |issue= 1 |pages= 24–33 |year= 1995 |pmid= 7539106 |doi=10.1210/me.9.1.24
*cite journal | author=Doody GM, Justement LB, Delibrias CC, "et al." |title=A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. |journal=Science |volume=269 |issue= 5221 |pages= 242–4 |year= 1995 |pmid= 7618087 |doi=10.1126/science.7618087
*cite journal | author=Yetter A, Uddin S, Krolewski JJ, "et al." |title=Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase. |journal=J. Biol. Chem. |volume=270 |issue= 31 |pages= 18179–82 |year= 1995 |pmid= 7629131 |doi=10.1074/jbc.270.31.18179
*cite journal | author=Banville D, Stocco R, Shen SH |title=Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts. |journal=Genomics |volume=27 |issue= 1 |pages= 165–73 |year= 1995 |pmid= 7665165 |doi= 10.1006/geno.1995.1020
*cite journal | author=Yi T, Ihle JN |title=Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand. |journal=Mol. Cell. Biol. |volume=13 |issue= 6 |pages= 3350–8 |year= 1993 |pmid= 7684496 |doi=
*cite journal | author=D'Ambrosio D, Hippen KL, Minskoff SA, "et al." |title=Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. |journal=Science |volume=268 |issue= 5208 |pages= 293–7 |year= 1995 |pmid= 7716523 |doi=10.1126/science.7716523
*cite journal | author=Li RY, Gaits F, Ragab A, "et al." |title=Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein. |journal=Embo J. |volume=14 |issue= 11 |pages= 2519–26 |year= 1995 |pmid= 7781604 |doi=
*cite journal | author=Klingmüller U, Lorenz U, Cantley LC, "et al." |title=Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. |journal=Cell |volume=80 |issue= 5 |pages= 729–38 |year= 1995 |pmid= 7889566 |doi=10.1016/0092-8674(95)90351-8
*cite journal | author=Lorenz U, Ravichandran KS, Pei D, "et al." |title=Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells. |journal=Mol. Cell. Biol. |volume=14 |issue= 3 |pages= 1824–34 |year= 1994 |pmid= 8114715 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8
*cite journal | author=Yi T, Mui AL, Krystal G, Ihle JN |title=Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7577–86 |year= 1994 |pmid= 8246974 |doi=

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