PKP4

Plakophilin 4, also known as PKP4, is a human gene.cite web | title = Entrez Gene: PKP4 plakophilin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8502| accessdate = ]

PBB_Summary
section_title =
summary_text = Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms.cite web | title = Entrez Gene: PKP4 plakophilin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8502| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Keil R, Wolf A, Hüttelmaier S, Hatzfeld M |title=Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin. |journal=Cell Cycle |volume=6 |issue= 2 |pages= 122–7 |year= 2007 |pmid= 17264675 |doi=
*cite journal | author=Hatzfeld M, Nachtsheim C |title=Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins. |journal=J. Cell. Sci. |volume=109 ( Pt 11) |issue= |pages= 2767–78 |year= 1997 |pmid= 8937994 |doi=
*cite journal | author=Paffenholz R, Franke WW |title=Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family. |journal=Differentiation |volume=61 |issue= 5 |pages= 293–304 |year= 1997 |pmid= 9342840 |doi=
*cite journal | author=Bonné S, van Hengel J, van Roy F |title=Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily. |journal=Genomics |volume=51 |issue= 3 |pages= 452–4 |year= 1998 |pmid= 9721216 |doi= 10.1006/geno.1998.5398
*cite journal | author=Levesque G, Yu G, Nishimura M, "et al." |title=Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin. |journal=J. Neurochem. |volume=72 |issue= 3 |pages= 999–1008 |year= 1999 |pmid= 10037471 |doi=
*cite journal | author=Stahl B, Diehlmann A, Südhof TC |title=Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071. |journal=J. Biol. Chem. |volume=274 |issue= 14 |pages= 9141–8 |year= 1999 |pmid= 10092585 |doi=
*cite journal | author=Deguchi M, Iizuka T, Hata Y, "et al." |title=PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29875–80 |year= 2000 |pmid= 10896674 |doi= 10.1074/jbc.M005384200
*cite journal | author=Schröder R, van der Ven PF, Warlo I, "et al." |title=p0071, a member of the armadillo multigene family, is a constituent of sarcomeric I-bands in human skeletal muscle. |journal=J. Muscle Res. Cell. Motil. |volume=21 |issue= 6 |pages= 577–86 |year= 2001 |pmid= 11206135 |doi=
*cite journal | author=Jaulin-Bastard F, Arsanto JP, Le Bivic A, "et al." |title=Interaction between Erbin and a Catenin-related protein in epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 4 |pages= 2869–75 |year= 2002 |pmid= 11711544 |doi= 10.1074/jbc.M109652200
*cite journal | author=Izawa I, Nishizawa M, Tomono Y, "et al." |title=ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells. |journal=Genes Cells |volume=7 |issue= 5 |pages= 475–85 |year= 2002 |pmid= 12047349 |doi=
*cite journal | author=Ohno H, Hirabayashi S, Iizuka T, "et al." |title=Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells. |journal=Oncogene |volume=21 |issue= 46 |pages= 7042–9 |year= 2002 |pmid= 12370826 |doi= 10.1038/sj.onc.1205852
*cite journal | author=Calkins CC, Hoepner BL, Law CM, "et al." |title=The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein. |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1774–83 |year= 2003 |pmid= 12426320 |doi= 10.1074/jbc.M205693200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Salomon AR, Ficarro SB, Brill LM, "et al." |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443–8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100
*cite journal | author=Hatzfeld M, Green KJ, Sauter H |title=Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains. |journal=J. Cell. Sci. |volume=116 |issue= Pt 7 |pages= 1219–33 |year= 2003 |pmid= 12615965 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Setzer SV, Calkins CC, Garner J, "et al." |title=Comparative analysis of armadillo family proteins in the regulation of a431 epithelial cell junction assembly, adhesion and migration. |journal=J. Invest. Dermatol. |volume=123 |issue= 3 |pages= 426–33 |year= 2004 |pmid= 15304078 |doi= 10.1111/j.0022-202X.2004.23319.x
*cite journal | author=Zhang Y, Wolf-Yadlin A, Ross PL, "et al." |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200
*cite journal | author=Tao WA, Wollscheid B, O'Brien R, "et al." |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591–8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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