- Delta catenin
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catenin (cadherin-associated protein), delta 1 Identifiers Symbol CTNND1 Alt. symbols CTNND Entrez 1500 HUGO 2515 OMIM 601045 RefSeq NM_001331 UniProt O60716 Other data Locus Chr. 11 q12.1 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) Identifiers Symbol CTNND2 Entrez 1501 HUGO 2516 OMIM 604275 RefSeq NM_001332 UniProt Q9UQB3 Other data Locus Chr. 5 p15.2 Delta-1-catenin and Delta-2-catenin are members of a subfamily of proteins with ten Armadillo-repeats. Delta-2-catenin is expressed in the brain where it is important for normal cognitive development.[1] Like beta-catenin and gamma-catenin, delta-catenins seem to interact with presenilins.[2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion.[3]
While beta-catenin acts as a transcription reglatory protein in the Wnt/TCF pathway, delta-catenin has been implicated as a regulator of the NF-κB transcription factor.[4]
References
- ^ Israely I, Costa RM, Xie CW, Silva AJ, Kosik KS, Liu X (September 2004). "Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction". Curr. Biol. 14 (18): 1657–63. doi:10.1016/j.cub.2004.08.065. PMID 15380068. http://linkinghub.elsevier.com/retrieve/pii/S0960982204006761.
- ^ Rubio ME, Curcio C, Chauvet N, Brusés JL (December 2005). "Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1". Mol. Cell. Neurosci. 30 (4): 611–23. doi:10.1016/j.mcn.2005.06.005. PMID 16456928.
- ^ Teo JL, Ma H, Nguyen C, Lam C, Kahn M (August 2005). "Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation". Proc. Natl. Acad. Sci. U.S.A. 102 (34): 12171–6. doi:10.1073/pnas.0504600102. PMC 1189325. PMID 16093313. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=16093313.
- ^ Perez-Moreno M, Davis MA, Wong E, Pasolli HA, Reynolds AB, Fuchs E (February 2006). "p120-catenin mediates inflammatory responses in the skin". Cell 124 (3): 631–44. doi:10.1016/j.cell.2005.11.043. PMC 2443688. PMID 16469707. http://linkinghub.elsevier.com/retrieve/pii/S0092-8674(06)00008-0.
See also
Proteins of the cytoskeleton Human I (MYO1A, MYO1B, MYO1C, MYO1D, MYO1E, MYO1F, MYO1G, MYO1H) · II (MYH1, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYH10, MYH11, MYH13, MYH14, MYH15, MYH16) · III (MYO3A, MYO3B) · V (MYO5A, MYO5B, MYO5C) · VI (MYO6) · VII (MYO7A, MYO7B) · IX (MYO9A, MYO9B) · X (MYO10) · XV (MYO15A) · XVIII (MYO18A, MYO18B) · LC (MYL1, MYL2, MYL3, MYL4, MYL5, MYL6, MYL6B, MYL7, MYL9, MYLIP, MYLK, MYLK2, MYLL1)OtherOtherEpithelial keratins
(soft alpha-keratins)Ungrouped alphaNot alphaType 3Type 4Type 5OtherOtherNonhuman Categories:- Genes on chromosome 11
- Genes on chromosome 5
- Chromosome 11 gene stubs
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