MYH11

MYH11

Myosin, heavy chain 11, smooth muscle, also known as MYH11, is a human gene.cite web | title = Entrez Gene: MYH11 myosin, heavy chain 11, smooth muscle| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4629| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: MYH11 myosin, heavy chain 11, smooth muscle| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4629| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Babu GJ, Warshaw DM, Periasamy M |title=Smooth muscle myosin heavy chain isoforms and their role in muscle physiology. |journal=Microsc. Res. Tech. |volume=50 |issue= 6 |pages= 532–40 |year= 2000 |pmid= 10998642 |doi= 10.1002/1097-0029(20000915)50:6<532::AID-JEMT10>3.0.CO;2-E |doilabel=10.1002/1097-0029(20000915)50:6532::AID-JEMT103.0.CO;2-E
*cite journal | author=Matsuoka R, Yoshida MC, Furutani Y, "et al." |title=Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12. |journal=Am. J. Med. Genet. |volume=46 |issue= 1 |pages= 61–7 |year= 1993 |pmid= 7684189 |doi= 10.1002/ajmg.1320460110
*cite journal | author=Aikawa M, Sivam PN, Kuro-o M, "et al." |title=Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. |journal=Circ. Res. |volume=73 |issue= 6 |pages= 1000–12 |year= 1993 |pmid= 7916668 |doi=
*cite journal | author=van der Reijden BA, Dauwerse JG, Wessels JW, "et al." |title=A gene for a myosin peptide is disrupted by the inv(16)(p13q22) in acute nonlymphocytic leukemia M4Eo. |journal=Blood |volume=82 |issue= 10 |pages= 2948–52 |year= 1993 |pmid= 8219185 |doi=
*cite journal | author=Deng Z, Liu P, Marlton P, "et al." |title=Smooth muscle myosin heavy chain locus (MYH11) maps to 16p13.13-p13.12 and establishes a new region of conserved synteny between human 16p and mouse 16. |journal=Genomics |volume=18 |issue= 1 |pages= 156–9 |year= 1994 |pmid= 8276405 |doi= 10.1006/geno.1993.1443
*cite journal | author=Shoeman RL, Sachse C, Höner B, "et al." |title=Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin. |journal=Am. J. Pathol. |volume=142 |issue= 1 |pages= 221–30 |year= 1993 |pmid= 8424456 |doi=
*cite journal | author=New L, Jiang Y, Zhao M, "et al." |title=PRAK, a novel protein kinase regulated by the p38 MAP kinase. |journal=EMBO J. |volume=17 |issue= 12 |pages= 3372–84 |year= 1998 |pmid= 9628874 |doi= 10.1093/emboj/17.12.3372
*cite journal | author=Tanaka Y, Fujii M, Hayashi K, "et al." |title=The chimeric protein, PEBP2 beta/CBF beta-SMMHC, disorganizes cytoplasmic stress fibers and inhibits transcriptional activation. |journal=Oncogene |volume=17 |issue= 6 |pages= 699–708 |year= 1998 |pmid= 9715271 |doi= 10.1038/sj.onc.1201985
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=
*cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, "et al." |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927
*cite journal | author=Tsuchio Y, Naito S, Nogami A, "et al." |title=Intracoronary serum smooth muscle myosin heavy chain levels following PTCA may predict restenosis. |journal=Japanese heart journal |volume=41 |issue= 2 |pages= 131–40 |year= 2000 |pmid= 10850529 |doi=
*cite journal | author=Lin VK, Wang D, Lee IL, "et al." |title=Myosin heavy chain gene expression in normal and hyperplastic human prostate tissue. |journal=Prostate |volume=44 |issue= 3 |pages= 193–203 |year= 2000 |pmid= 10906735 |doi=
*cite journal | author=Meloni I, Rubegni P, De Aloe G, "et al." |title=Pseudoxanthoma elasticum: Point mutations in the ABCC6 gene and a large deletion including also ABCC1 and MYH11. |journal=Hum. Mutat. |volume=18 |issue= 1 |pages= 85 |year= 2001 |pmid= 11439001 |doi= 10.1002/humu.1157
*cite journal | author=Kundu M, Chen A, Anderson S, "et al." |title=Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. |journal=Blood |volume=100 |issue= 7 |pages= 2449–56 |year= 2002 |pmid= 12239155 |doi= 10.1182/blood-2002-04-1064
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Landrette SF, Kuo YH, Hensen K, "et al." |title=Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. |journal=Blood |volume=105 |issue= 7 |pages= 2900–7 |year= 2005 |pmid= 15585652 |doi= 10.1182/blood-2004-09-3630
*cite journal | author=Léguillette R, Gil FR, Zitouni N, "et al." |title=(+)Insert smooth muscle myosin heavy chain (SM-B) isoform expression in human tissues. |journal=Am. J. Physiol., Cell Physiol. |volume=289 |issue= 5 |pages= C1277–85 |year= 2005 |pmid= 16000639 |doi= 10.1152/ajpcell.00244.2004
*cite journal | author=Zhu L, Vranckx R, Khau Van Kien P, "et al." |title=Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. |journal=Nat. Genet. |volume=38 |issue= 3 |pages= 343–9 |year= 2006 |pmid= 16444274 |doi= 10.1038/ng1721

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