ACTC1

Actin, alpha, cardiac muscle 1, also known as ACTC1, is a human gene.cite web | title = Entrez Gene: ACTC1 actin, alpha, cardiac muscle 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=70| accessdate = ]

PBB_Summary
section_title =
summary_text = Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).cite web | title = Entrez Gene: ACTC1 actin, alpha, cardiac muscle 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=70| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease. |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227–30 |year= 1997 |pmid= 8997639 |doi=
*cite journal | author=Bearer EL, Prakash JM, Li Z |title=Actin dynamics in platelets. |journal=Int. Rev. Cytol. |volume=217 |issue= |pages= 137–82 |year= 2002 |pmid= 12019562 |doi=
*cite journal | author=Elzinga M, Maron BJ, Adelstein RS |title=Human heart and platelet actins are products of different genes. |journal=Science |volume=191 |issue= 4222 |pages= 94–5 |year= 1976 |pmid= 1246600 |doi=
*cite journal | author=Adams LD, Tomasselli AG, Robbins P, "et al." |title=HIV-1 protease cleaves actin during acute infection of human T-lymphocytes. |journal=AIDS Res. Hum. Retroviruses |volume=8 |issue= 2 |pages= 291–5 |year= 1992 |pmid= 1540415 |doi=
*cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=
*cite journal | author=Kramer PL, Luty JA, Litt M |title=Regional localization of the gene for cardiac muscle actin (ACTC) on chromosome 15q. |journal=Genomics |volume=13 |issue= 3 |pages= 904–5 |year= 1992 |pmid= 1639426 |doi=
*cite journal | author=Watkins C, Bodfish P, Warne D, "et al." |title=Dinucleotide repeat polymorphism in the human alpha-cardiac actin gene, intron IV (ACTC), detected using the polymerase chain reaction. |journal=Nucleic Acids Res. |volume=19 |issue= 24 |pages= 6980 |year= 1992 |pmid= 1762945 |doi=
*cite journal | author=Tomasselli AG, Hui JO, Adams L, "et al." |title=Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus. |journal=J. Biol. Chem. |volume=266 |issue= 22 |pages= 14548–53 |year= 1991 |pmid= 1907279 |doi=
*cite journal | author=Shoeman RL, Kesselmier C, Mothes E, "et al." |title=Non-viral cellular substrates for human immunodeficiency virus type 1 protease. |journal=FEBS Lett. |volume=278 |issue= 2 |pages= 199–203 |year= 1991 |pmid= 1991513 |doi=
*cite journal | author=Buckingham M, Alonso S, Barton P, "et al." |title=Actin and myosin multigene families: their expression during the formation and maturation of striated muscle. |journal=Am. J. Med. Genet. |volume=25 |issue= 4 |pages= 623–34 |year= 1987 |pmid= 3789022 |doi= 10.1002/ajmg.1320250405
*cite journal | author=Engel JN, Gunning PW, Kedes L |title=Isolation and characterization of human actin genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=78 |issue= 8 |pages= 4674–8 |year= 1982 |pmid= 6272269 |doi=
*cite journal | author=Humphries SE, Whittall R, Minty A, "et al." |title=There are approximately 20 actin gene in the human genome. |journal=Nucleic Acids Res. |volume=9 |issue= 19 |pages= 4895–908 |year= 1982 |pmid= 6273789 |doi=
*cite journal | author=Hamada H, Petrino MG, Kakunaga T |title=Molecular structure and evolutionary origin of human cardiac muscle actin gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=79 |issue= 19 |pages= 5901–5 |year= 1983 |pmid= 6310553 |doi=
*cite journal | author=Gunning P, Ponte P, Kedes L, "et al." |title=Chromosomal location of the co-expressed human skeletal and cardiac actin genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 6 |pages= 1813–7 |year= 1984 |pmid= 6584914 |doi=
*cite journal | author=Gunning P, Ponte P, Blau H, Kedes L |title=alpha-skeletal and alpha-cardiac actin genes are coexpressed in adult human skeletal muscle and heart. |journal=Mol. Cell. Biol. |volume=3 |issue= 11 |pages= 1985–95 |year= 1984 |pmid= 6689196 |doi=
*cite journal | author=Ueyama H, Inazawa J, Ariyama T, "et al." |title=Reexamination of chromosomal loci of human muscle actin genes by fluorescence in situ hybridization. |journal=Jpn. J. Hum. Genet. |volume=40 |issue= 1 |pages= 145–8 |year= 1995 |pmid= 7780165 |doi=
*cite journal | author=Moroianu J, Riordan JF |title=Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 5 |pages= 1677–81 |year= 1994 |pmid= 8127865 |doi=
*cite journal | author=Dunwoodie SL, Joya JE, Arkell RM, Hardeman EC |title=Multiple regions of the human cardiac actin gene are necessary for maturation-based expression in striated muscle. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 12212–9 |year= 1994 |pmid= 8163527 |doi=
*cite journal | author=Shuster CB, Lin AY, Nayak R, Herman IM |title=Beta cap73: a novel beta actin-specific binding protein. |journal=Cell Motil. Cytoskeleton |volume=35 |issue= 3 |pages= 175–87 |year= 1997 |pmid= 8913639 |doi= 10.1002/(SICI)1097-0169(1996)35:3<175::AID-CM1>3.0.CO;2-8 |doilabel=10.1002/(SICI)1097-0169(1996)35:3175::AID-CM13.0.CO;2-8

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