MYO1A

Myosin IA, also known as Brush-border myosin-1 and MYO1A, is a human gene.cite web | title = Entrez Gene: MYO1A myosin IA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4640| accessdate = ]

The protein encoded by this gene belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding 'neck' region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site for calmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At the C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The myosin-1a protein is expressed by enterocytes, the epithelial cells that line the luminal surface of the small intestine. In these cells the myosin-1a protein localizes specifically to the brush border. Experiments indicate that the brush border population of the encoded protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the myosin-1a protein binds to the actin core bundle, which turns over on a much slower timescale.cite journal | author = Tyska MJ, Mooseker MS | title = MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells | journal = Biophys. J. | volume = 82 | issue = 4 | pages = 1869–83 | year = 2002 | month = April | pmid = 11916846 | pmc = 1301984 | url = http://www.biophysj.org/cgi/content/abstract/82/4/1869 | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hofmann WA, Johnson T, Klapczynski M, "et al." |title=From transcription to transport: emerging roles for nuclear myosin I. |journal=Biochem. Cell Biol. |volume=84 |issue= 4 |pages= 418–26 |year= 2007 |pmid= 16936815 |doi= 10.1139/o06-069
*cite journal | author=Hoshimaru M, Fujio Y, Sobue K, "et al." |title=Immunochemical evidence that myosin I heavy chain-like protein is identical to the 110-kilodalton brush-border protein. |journal=J. Biochem. |volume=106 |issue= 3 |pages= 455–9 |year= 1990 |pmid= 2606897 |doi=
*cite journal | author=Bement WM, Hasson T, Wirth JA, "et al." |title=Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6549–53 |year= 1994 |pmid= 8022818 |doi=
*cite journal | author=Durrbach A, Collins K, Matsudaira P, "et al." |title=Brush border myosin-I truncated in the motor domain impairs the distribution and the function of endocytic compartments in an hepatoma cell line. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 14 |pages= 7053–8 |year= 1996 |pmid= 8692943 |doi=
*cite journal | author=Hasson T, Skowron JF, Gilbert DJ, "et al." |title=Mapping of unconventional myosins in mouse and human. |journal=Genomics |volume=36 |issue= 3 |pages= 431–9 |year= 1997 |pmid= 8884266 |doi= 10.1006/geno.1996.0488
*cite journal | author=Skowron JF, Bement WM, Mooseker MS |title=Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells. |journal=Cell Motil. Cytoskeleton |volume=41 |issue= 4 |pages= 308–24 |year= 1999 |pmid= 9858156 |doi= 10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J |doilabel=10.1002/(SICI)1097-0169(1998)41:4308::AID-CM43.0.CO;2-J
*cite journal | author=Li W, Wang J, Coluccio LM, "et al." |title=Brush border myosin I (BBMI): a basally localized transcript in human jejunal enterocytes. |journal=J. Histochem. Cytochem. |volume=48 |issue= 1 |pages= 89–94 |year= 2000 |pmid= 10653589 |doi=
*cite journal | author=Otterbein LR, Graceffa P, Dominguez R |title=The crystal structure of uncomplexed actin in the ADP state. |journal=Science |volume=293 |issue= 5530 |pages= 708–11 |year= 2001 |pmid= 11474115 |doi= 10.1126/science.1059700
*cite journal | author=Tyska MJ, Mooseker MS |title=MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells. |journal=Biophys. J. |volume=82 |issue= 4 |pages= 1869–83 |year= 2002 |pmid= 11916846 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=D'Adamo P, Pinna M, Capobianco S, "et al." |title=A novel autosomal dominant non-syndromic deafness locus (DFNA48) maps to 12q13-q14 in a large Italian family. |journal=Hum. Genet. |volume=112 |issue= 3 |pages= 319–20 |year= 2003 |pmid= 12596055 |doi= 10.1007/s00439-002-0880-6
*cite journal | author=Donaudy F, Ferrara A, Esposito L, "et al." |title=Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss. |journal=Am. J. Hum. Genet. |volume=72 |issue= 6 |pages= 1571–7 |year= 2003 |pmid= 12736868 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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