- MYO1A
Myosin IA, also known as Brush-border myosin-1 and MYO1A, is a human
gene .cite web | title = Entrez Gene: MYO1A myosin IA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4640| accessdate = ]The
protein encoded by this gene belongs to themyosin superfamily. Myosins are molecular motors that, upon interaction withactin filaments, utilize energy fromATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding 'neck' region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site forcalmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At theC-terminus , each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The myosin-1a protein is expressed byenterocytes , the epithelial cells that line the luminal surface of the small intestine. In these cells the myosin-1a protein localizes specifically to thebrush border . Experiments indicate that the brush border population of the encoded protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the myosin-1a protein binds to the actin core bundle, which turns over on a much slower timescale.cite journal | author = Tyska MJ, Mooseker MS | title = MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells | journal = Biophys. J. | volume = 82 | issue = 4 | pages = 1869–83 | year = 2002 | month = April | pmid = 11916846 | pmc = 1301984 | url = http://www.biophysj.org/cgi/content/abstract/82/4/1869 | issn = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Hofmann WA, Johnson T, Klapczynski M, "et al." |title=From transcription to transport: emerging roles for nuclear myosin I. |journal=Biochem. Cell Biol. |volume=84 |issue= 4 |pages= 418–26 |year= 2007 |pmid= 16936815 |doi= 10.1139/o06-069
*cite journal | author=Hoshimaru M, Fujio Y, Sobue K, "et al." |title=Immunochemical evidence that myosin I heavy chain-like protein is identical to the 110-kilodalton brush-border protein. |journal=J. Biochem. |volume=106 |issue= 3 |pages= 455–9 |year= 1990 |pmid= 2606897 |doi=
*cite journal | author=Bement WM, Hasson T, Wirth JA, "et al." |title=Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6549–53 |year= 1994 |pmid= 8022818 |doi=
*cite journal | author=Durrbach A, Collins K, Matsudaira P, "et al." |title=Brush border myosin-I truncated in the motor domain impairs the distribution and the function of endocytic compartments in an hepatoma cell line. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 14 |pages= 7053–8 |year= 1996 |pmid= 8692943 |doi=
*cite journal | author=Hasson T, Skowron JF, Gilbert DJ, "et al." |title=Mapping of unconventional myosins in mouse and human. |journal=Genomics |volume=36 |issue= 3 |pages= 431–9 |year= 1997 |pmid= 8884266 |doi= 10.1006/geno.1996.0488
*cite journal | author=Skowron JF, Bement WM, Mooseker MS |title=Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells. |journal=Cell Motil. Cytoskeleton |volume=41 |issue= 4 |pages= 308–24 |year= 1999 |pmid= 9858156 |doi= 10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J |doilabel=10.1002/(SICI)1097-0169(1998)41:4308::AID-CM43.0.CO;2-J
*cite journal | author=Li W, Wang J, Coluccio LM, "et al." |title=Brush border myosin I (BBMI): a basally localized transcript in human jejunal enterocytes. |journal=J. Histochem. Cytochem. |volume=48 |issue= 1 |pages= 89–94 |year= 2000 |pmid= 10653589 |doi=
*cite journal | author=Otterbein LR, Graceffa P, Dominguez R |title=The crystal structure of uncomplexed actin in the ADP state. |journal=Science |volume=293 |issue= 5530 |pages= 708–11 |year= 2001 |pmid= 11474115 |doi= 10.1126/science.1059700
*cite journal | author=Tyska MJ, Mooseker MS |title=MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells. |journal=Biophys. J. |volume=82 |issue= 4 |pages= 1869–83 |year= 2002 |pmid= 11916846 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=D'Adamo P, Pinna M, Capobianco S, "et al." |title=A novel autosomal dominant non-syndromic deafness locus (DFNA48) maps to 12q13-q14 in a large Italian family. |journal=Hum. Genet. |volume=112 |issue= 3 |pages= 319–20 |year= 2003 |pmid= 12596055 |doi= 10.1007/s00439-002-0880-6
*cite journal | author=Donaudy F, Ferrara A, Esposito L, "et al." |title=Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss. |journal=Am. J. Hum. Genet. |volume=72 |issue= 6 |pages= 1571–7 |year= 2003 |pmid= 12736868 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504PBB_Controls
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