MYO1C

MYO1C

Myosin IC, also known as MYO1C, is a human gene.cite web | title = Entrez Gene: MYO1C myosin IC| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4641| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19.cite web | title = Entrez Gene: MYO1C myosin IC| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4641| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ruppert C, Godel J, Müller RT, "et al." |title=Localization of the rat myosin I molecules myr 1 and myr 2 and in vivo targeting of their tail domains. |journal=J. Cell. Sci. |volume=108 ( Pt 12) |issue= |pages= 3775–86 |year= 1997 |pmid= 8719884 |doi=
*cite journal | author=Hasson T, Skowron JF, Gilbert DJ, "et al." |title=Mapping of unconventional myosins in mouse and human. |journal=Genomics |volume=36 |issue= 3 |pages= 431–9 |year= 1997 |pmid= 8884266 |doi= 10.1006/geno.1996.0488
*cite journal | author=Crozet F, el Amraoui A, Blanchard S, "et al." |title=Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. |journal=Genomics |volume=40 |issue= 2 |pages= 332–41 |year= 1997 |pmid= 9119401 |doi=
*cite journal | author=Skowron JF, Bement WM, Mooseker MS |title=Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells. |journal=Cell Motil. Cytoskeleton |volume=41 |issue= 4 |pages= 308–24 |year= 1999 |pmid= 9858156 |doi= 10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J |doilabel=10.1002/(SICI)1097-0169(1998)41:4308::AID-CM43.0.CO;2-J
*cite journal | author=Pestic-Dragovich L, Stojiljkovic L, Philimonenko AA, "et al." |title=A myosin I isoform in the nucleus. |journal=Science |volume=290 |issue= 5490 |pages= 337–41 |year= 2000 |pmid= 11030652 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Philimonenko VV, Zhao J, Iben S, "et al." |title=Nuclear actin and myosin I are required for RNA polymerase I transcription. |journal=Nat. Cell Biol. |volume=6 |issue= 12 |pages= 1165–72 |year= 2005 |pmid= 15558034 |doi= 10.1038/ncb1190
*cite journal | author=Kyselá K, Philimonenko AA, Philimonenko VV, "et al." |title=Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell. |journal=Histochem. Cell Biol. |volume=124 |issue= 5 |pages= 347–58 |year= 2005 |pmid= 16133118 |doi= 10.1007/s00418-005-0042-8
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Cavellán E, Asp P, Percipalle P, Farrants AK |title=The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription. |journal=J. Biol. Chem. |volume=281 |issue= 24 |pages= 16264–71 |year= 2006 |pmid= 16603771 |doi= 10.1074/jbc.M600233200
*cite journal | author=Cisterna B, Necchi D, Prosperi E, Biggiogera M |title=Small ribosomal subunits associate with nuclear myosin and actin in transit to the nuclear pores. |journal=FASEB J. |volume=20 |issue= 11 |pages= 1901–3 |year= 2006 |pmid= 16877530 |doi= 10.1096/fj.05-5278fje
*cite journal | author=Kahle M, Pridalová J, Spacek M, "et al." |title=Nuclear myosin is ubiquitously expressed and evolutionary conserved in vertebrates. |journal=Histochem. Cell Biol. |volume=127 |issue= 2 |pages= 139–48 |year= 2007 |pmid= 16957816 |doi= 10.1007/s00418-006-0231-0
*cite journal | author=Hofmann WA, Vargas GM, Ramchandran R, "et al." |title=Nuclear myosin I is necessary for the formation of the first phosphodiester bond during transcription initiation by RNA polymerase II. |journal=J. Cell. Biochem. |volume=99 |issue= 4 |pages= 1001–9 |year= 2006 |pmid= 16960872 |doi= 10.1002/jcb.21035
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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