SPTAN1

SPTAN1

Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), also known as SPTAN1, is a human gene.cite web | title = Entrez Gene: SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)| url = http://mcb.asm.org/cgi/content/abstract/8/1/1 | accessdate = ] cite journal | author = Leto TL, Fortugno-Erikson D, Barton D, Yang-Feng TL, Francke U, Harris AS, Morrow JS, Marchesi VT, Benz EJ Jr | title = Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species | journal = Mol. Cell. Biol. | volume = 8 | issue = 1 | pages = 1–9 | year = 1988 | month = January | pmid = 3336352 | pmc = 363070 | doi = | url = http://mcb.asm.org/cgi/pmidlookup?view=long&pmid=3336352 | issn = ] cite journal | author = McMahon AP, Giebelhaus DH, Champion JE, "et al" | title = cDNA cloning, sequencing and chromosome mapping of a non-erythroid spectrin, human alpha-fodrin | journal = Differentiation | volume = 34 | issue = 1 | pages = 68–78 | year = 1987 | pmid = 3038643 | url = | issn = ]

The spectrins are a family of widely-distributed cytoskeletal proteins which are involved in actin crosslinking. The protein enocoded by this gene is an spectrin alpha-chain which heterodimerizes with tissue-specific beta-chains.

ee also

* Sjögren's syndrome

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chow CW |title=Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3. |journal=Clinical and investigative medicine. Médecine clinique et experimentale |volume=22 |issue= 5 |pages= 195–206 |year= 1999 |pmid= 10579058 |doi=
*cite journal | author=Hayashi Y, Arakaki R, Ishimaru N |title=The role of caspase cascade on the development of primary Sjögren's syndrome. |journal=J. Med. Invest. |volume=50 |issue= 1-2 |pages= 32–8 |year= 2003 |pmid= 12630566 |doi=
*cite journal | author=Bennett V |title=Immunoreactive forms of human erythrocyte ankyrin are present in diverse cells and tissues. |journal=Nature |volume=281 |issue= 5732 |pages= 597–9 |year= 1979 |pmid= 492324 |doi=
*cite journal | author=Frappier T, Stetzkowski-Marden F, Pradel LA |title=Interaction domains of neurofilament light chain and brain spectrin. |journal=Biochem. J. |volume=275 ( Pt 2) |issue= |pages= 521–7 |year= 1991 |pmid= 1902666 |doi=
*cite journal | author=Bennett AF, Hayes NV, Baines AJ |title=Site specificity in the interactions of synapsin 1 with tubulin. |journal=Biochem. J. |volume=276 ( Pt 3) |issue= |pages= 793–9 |year= 1991 |pmid= 1905928 |doi=
*cite journal | author=Davis LH, Bennett V |title=Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin. |journal=J. Biol. Chem. |volume=265 |issue= 18 |pages= 10589–96 |year= 1990 |pmid= 2141335 |doi=
*cite journal | author=Moon RT, McMahon AP |title=Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin. |journal=J. Biol. Chem. |volume=265 |issue= 8 |pages= 4427–33 |year= 1990 |pmid= 2307671 |doi=
*cite journal | author=Langley RC, Cohen CM |title=Association of spectrin with desmin intermediate filaments. |journal=J. Cell. Biochem. |volume=30 |issue= 2 |pages= 101–9 |year= 1986 |pmid= 2939097 |doi= 10.1002/jcb.240300202
*cite journal | author=Cianci CD, Giorgi M, Morrow JS |title=Phosphorylation of ankyrin down-regulates its cooperative interaction with spectrin and protein 3. |journal=J. Cell. Biochem. |volume=37 |issue= 3 |pages= 301–15 |year= 1988 |pmid= 2970468 |doi= 10.1002/jcb.240370305
*cite journal | author=Steiner JP, Bennett V |title=Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin. |journal=J. Biol. Chem. |volume=263 |issue= 28 |pages= 14417–25 |year= 1988 |pmid= 2971657 |doi=
*cite journal | author=Herrmann H, Wiche G |title=Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin. |journal=J. Biol. Chem. |volume=262 |issue= 3 |pages= 1320–5 |year= 1987 |pmid= 3027087 |doi=
*cite journal | author=McMahon AP, Giebelhaus DH, Champion JE, "et al." |title=cDNA cloning, sequencing and chromosome mapping of a non-erythroid spectrin, human alpha-fodrin. |journal=Differentiation |volume=34 |issue= 1 |pages= 68–78 |year= 1987 |pmid= 3038643 |doi=
*cite journal | author=Frappier T, Regnouf F, Pradel LA |title=Binding of brain spectrin to the 70-kDa neurofilament subunit protein. |journal=Eur. J. Biochem. |volume=169 |issue= 3 |pages= 651–7 |year= 1988 |pmid= 3121319 |doi=
*cite journal | author=Leto TL, Fortugno-Erikson D, Barton D, "et al." |title=Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species. |journal=Mol. Cell. Biol. |volume=8 |issue= 1 |pages= 1–9 |year= 1988 |pmid= 3336352 |doi=
*cite journal | author=McMahon AP, Moon RT |title=Structure and evolution of a non-erythroid spectrin, human alpha-fodrin. |journal=Biochem. Soc. Trans. |volume=15 |issue= 5 |pages= 804–7 |year= 1988 |pmid= 3691949 |doi=
*cite journal | author=Lundberg S, Björk J, Löfvenberg L, Backman L |title=Cloning, expression and characterization of two putative calcium-binding sites in human non-erythroid alpha-spectrin. |journal=Eur. J. Biochem. |volume=230 |issue= 2 |pages= 658–65 |year= 1995 |pmid= 7607240 |doi=
*cite journal | author=Hughes CA, Bennett V |title=Adducin: a physical model with implications for function in assembly of spectrin-actin complexes. |journal=J. Biol. Chem. |volume=270 |issue= 32 |pages= 18990–6 |year= 1995 |pmid= 7642559 |doi=
*cite journal | author=Gregorio CC, Repasky EA, Fowler VM, Black JD |title=Dynamic properties of ankyrin in T lymphocytes: colocalization with spectrin and protein kinase C beta. |journal=J. Cell Biol. |volume=125 |issue= 2 |pages= 345–58 |year= 1994 |pmid= 8163551 |doi=
*cite journal | author=Li X, Bennett V |title=Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes. |journal=J. Biol. Chem. |volume=271 |issue= 26 |pages= 15695–702 |year= 1996 |pmid= 8663089 |doi=
*cite journal | author=Stabach PR, Cianci CD, Glantz SB, "et al." |title=Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility. |journal=Biochemistry |volume=36 |issue= 1 |pages= 57–65 |year= 1997 |pmid= 8993318 |doi= 10.1021/bi962034i

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