TERF1

Telomeric repeat binding factor (NIMA-interacting) 1, also known as TERF1, is a human gene.cite web | title = Entrez Gene: TERF1 telomeric repeat binding factor (NIMA-interacting) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7013| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.cite web | title = Entrez Gene: TERF1 telomeric repeat binding factor (NIMA-interacting) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7013| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhong Z, Shiue L, Kaplan S, de Lange T |title=A mammalian factor that binds telomeric TTAGGG repeats in vitro. |journal=Mol. Cell. Biol. |volume=12 |issue= 11 |pages= 4834–43 |year= 1992 |pmid= 1406665 |doi=
*cite journal | author=Chong L, van Steensel B, Broccoli D, "et al." |title=A human telomeric protein. |journal=Science |volume=270 |issue= 5242 |pages= 1663–7 |year= 1996 |pmid= 7502076 |doi=
*cite journal | author=Lu KP, Hanes SD, Hunter T |title=A human peptidyl-prolyl isomerase essential for regulation of mitosis. |journal=Nature |volume=380 |issue= 6574 |pages= 544–7 |year= 1996 |pmid= 8606777 |doi= 10.1038/380544a0
*cite journal | author=Bilaud T, Koering CE, Binet-Brasselet E, "et al." |title=The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human. |journal=Nucleic Acids Res. |volume=24 |issue= 7 |pages= 1294–303 |year= 1996 |pmid= 8614633 |doi=
*cite journal | author=Broccoli D, Chong L, Oelmann S, "et al." |title=Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains. |journal=Hum. Mol. Genet. |volume=6 |issue= 1 |pages= 69–76 |year= 1997 |pmid= 9002672 |doi=
*cite journal | author=Bianchi A, Smith S, Chong L, "et al." |title=TRF1 is a dimer and bends telomeric DNA. |journal=EMBO J. |volume=16 |issue= 7 |pages= 1785–94 |year= 1997 |pmid= 9130722 |doi= 10.1093/emboj/16.7.1785
*cite journal | author=Broccoli D, Smogorzewska A, Chong L, de Lange T |title=Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. |journal=Nat. Genet. |volume=17 |issue= 2 |pages= 231–5 |year= 1997 |pmid= 9326950 |doi= 10.1038/ng1097-231
*cite journal | author=Shen M, Haggblom C, Vogt M, "et al." |title=Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 25 |pages= 13618–23 |year= 1998 |pmid= 9391075 |doi=
*cite journal | author=Nosaka K, Kawahara M, Masuda M, "et al." |title=Association of nucleoside diphosphate kinase nm23-H2 with human telomeres. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 342–8 |year= 1998 |pmid= 9480811 |doi= 10.1006/bbrc.1997.8097
*cite journal | author=Nishikawa T, Nagadoi A, Yoshimura S, "et al." |title=Solution structure of the DNA-binding domain of human telomeric protein, hTRF1. |journal=Structure |volume=6 |issue= 8 |pages= 1057–65 |year= 1998 |pmid= 9739097 |doi=
*cite journal | author=Smith S, Giriat I, Schmitt A, de Lange T |title=Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. |journal=Science |volume=282 |issue= 5393 |pages= 1484–7 |year= 1998 |pmid= 9822378 |doi=
*cite journal | author=Kim SH, Kaminker P, Campisi J |title=TIN2, a new regulator of telomere length in human cells. |journal=Nat. Genet. |volume=23 |issue= 4 |pages= 405–12 |year= 1999 |pmid= 10581025 |doi= 10.1038/70508
*cite journal | author=Smogorzewska A, van Steensel B, Bianchi A, "et al." |title=Control of human telomere length by TRF1 and TRF2. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1659–68 |year= 2000 |pmid= 10669743 |doi=
*cite journal | author=Wu G, Lee WH, Chen PL |title=NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30618–22 |year= 2000 |pmid= 10913111 |doi= 10.1074/jbc.C000390200
*cite journal | author=Chi NW, Lodish HF |title=Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38437–44 |year= 2001 |pmid= 10988299 |doi= 10.1074/jbc.M007635200
*cite journal | author=Kishi S, Wulf G, Nakamura M, Lu KP |title=Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors. |journal=Oncogene |volume=20 |issue= 12 |pages= 1497–508 |year= 2001 |pmid= 11313893 |doi= 10.1038/sj.onc.1204229
*cite journal | author=Kishi S, Zhou XZ, Ziv Y, "et al." |title=Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29282–91 |year= 2001 |pmid= 11375976 |doi= 10.1074/jbc.M011534200
*cite journal | author=Fairall L, Chapman L, Moss H, "et al." |title=Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. |journal=Mol. Cell |volume=8 |issue= 2 |pages= 351–61 |year= 2001 |pmid= 11545737 |doi=
*cite journal | author=Zhou XZ, Lu KP |title=The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. |journal=Cell |volume=107 |issue= 3 |pages= 347–59 |year= 2001 |pmid= 11701125 |doi=
*cite journal | author=Nishikawa T, Okamura H, Nagadoi A, "et al." |title=Solution structure of a telomeric DNA complex of human TRF1. |journal=Structure |volume=9 |issue= 12 |pages= 1237–51 |year= 2002 |pmid= 11738049 |doi=

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