NME1

NME1
Non-metastatic cells 1, protein (NM23A) expressed in

PDB rendering based on 1be4.
Identifiers
Symbols NME1; AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1
External IDs OMIM: 156490 MGI: 97355 HomoloGene: 56418 GeneCards: NME1 Gene
EC number 2.7.4.6
Orthologs
Species Human Mouse
Entrez 4830 18102
Ensembl ENSG00000239672 ENSMUSG00000037601
UniProt P15531 Q5NC80
RefSeq (mRNA) NM_000269.2 NM_008704.2
RefSeq (protein) NP_000260.1 NP_032730.1
Location (UCSC) Chr 17:
49.23 – 49.24 Mb		 Chr 11:
93.82 – 93.83 Mb
PubMed search [1] [2]

Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene.[1] It is thought to be a metastasis suppressor.

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.[2]

Contents

Interactions

NME1 has been shown to interact with Aurora A kinase,[3] NME3,[4][5] Protein SET,[6] RAR-related orphan receptor alpha,[7] TERF1,[8] CD29[9] and RAR-related orphan receptor beta.[7]

See also

References

  1. ^ Dooley S, Seib T, Engel M, Theisinger B, Janz H, Piontek K, Zang KD, Welter C (Feb 1994). "Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1". Hum Genet 93 (1): 63–6. PMID 8270257. 
  2. ^ "Entrez Gene: NME1 non-metastatic cells 1, protein (NM23A) expressed in". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4830. 
  3. ^ Du, Jian; Hannon Gregory J (Dec. 2002). "The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1". Nucleic Acids Res. (England) 30 (24): 5465–75. doi:10.1093/nar/gkf678. PMC 140054. PMID 12490715. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140054. 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ Negroni, A; Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (Sep. 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. (ENGLAND) 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. ISSN 1350-9047. PMID 11042679. 
  6. ^ Fan, Zusen; Beresford Paul J, Oh David Y, Zhang Dong, Lieberman Judy (Mar. 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor". Cell (United States) 112 (5): 659–72. doi:10.1016/S0092-8674(03)00150-8. ISSN 0092-8674. PMID 12628186. 
  7. ^ a b Paravicini, G; Steinmayr M, André E, Becker-André M (Oct. 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. (UNITED STATES) 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. ISSN 0006-291X. PMID 8858107. 
  8. ^ Nosaka, K; Kawahara M, Masuda M, Satomi Y, Nishino H (Feb. 1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. (UNITED STATES) 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. ISSN 0006-291X. PMID 9480811. 
  9. ^ Fournier, Henri-Noël; Dupé-Manet Sandra, Bouvard Daniel, Lacombe Marie-Lise, Marie Christiane, Block Marc R, Albiges-Rizo Corinne (Jun. 2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem. (United States) 277 (23): 20895–902. doi:10.1074/jbc.M200200200. ISSN 0021-9258. PMID 11919189. 

Further reading

  • Freije JM, MacDonald NJ, Steeg PS (1998). "Nm23 and tumour metastasis: basic and translational advances". Biochem. Soc. Symp. 63: 261–71. PMID 9513729. 
  • Roymans D, Willems R, Van Blockstaele DR, Slegers H (2002). "Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis". Clin. Exp. Metastasis 19 (6): 465–76. doi:10.1023/A:1020396722860. PMID 12405283. 
  • Tee YT, Chen GD, Lin LY et al. (2007). "Nm23-H1: a metastasis-associated gene". Taiwanese journal of obstetrics & gynecology 45 (2): 107–13. doi:10.1016/S1028-4559(09)60206-0. PMID 17197349. 
  • Gilles AM, Presecan E, Vonica A, Lascu I (1991). "Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme". J. Biol. Chem. 266 (14): 8784–9. PMID 1851158. 
  • Leone A, McBride OW, Weston A et al. (1991). "Somatic allelic deletion of nm23 in human cancer". Cancer Res. 51 (9): 2490–3. PMID 2015608. 
  • Hailat N, Keim DR, Melhem RF et al. (1991). "High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification". J. Clin. Invest. 88 (1): 341–5. doi:10.1172/JCI115299. PMC 296039. PMID 2056128. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=296039. 
  • Rosengard AM, Krutzsch HC, Shearn A et al. (1989). "Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development". Nature 342 (6246): 177–80. doi:10.1038/342177a0. PMID 2509941. 
  • Wang L, Patel U, Ghosh L et al. (1993). "Mutation in the nm23 gene is associated with metastasis in colorectal cancer". Cancer Res. 53 (4): 717–20. PMID 7916650. 
  • Chang CL, Zhu XX, Thoraval DH et al. (1994). "Nm23-H1 mutation in neuroblastoma". Nature 370 (6488): 335–6. doi:10.1038/370335a0. PMID 8047138. 
  • MacDonald NJ, De la Rosa A, Benedict MA et al. (1994). "A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential". J. Biol. Chem. 268 (34): 25780–9. PMID 8245015. 
  • Postel EH, Berberich SJ, Flint SJ, Ferrone CA (1993). "Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis". Science 261 (5120): 478–80. doi:10.1126/science.8392752. PMID 8392752. 
  • Sudbrak R, Golla A, Hogan K et al. (1993). "Exclusion of malignant hyperthermia susceptibility (MHS) from a putative MHS2 locus on chromosome 17q and of the alpha 1, beta 1, and gamma subunits of the dihydropyridine receptor calcium channel as candidates for the molecular defect". Hum. Mol. Genet. 2 (7): 857–62. doi:10.1093/hmg/2.7.857. PMID 8395939. 
  • MacDonald NJ, Freije JM, Stracke ML et al. (1996). "Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells". J. Biol. Chem. 271 (41): 25107–16. doi:10.1074/jbc.271.41.25107. PMID 8810265. 
  • Paravicini G, Steinmayr M, André E, Becker-André M (1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107. 
  • Nosaka K, Kawahara M, Masuda M et al. (1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. PMID 9480811. 
  • Schaertl S, Konrad M, Geeves MA (1998). "Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis". J. Biol. Chem. 273 (10): 5662–9. doi:10.1074/jbc.273.10.5662. PMID 9488696. 
  • Willems R, Van Bockstaele DR, Lardon F et al. (1998). "Decrease in nucleoside diphosphate kinase (NDPK/nm23) expression during hematopoietic maturation". J. Biol. Chem. 273 (22): 13663–8. doi:10.1074/jbc.273.22.13663. PMID 9593706. 
  • Manda R, Kohno T, Matsuno Y et al. (1999). "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display". Genomics 61 (1): 5–14. doi:10.1006/geno.1999.5939. PMID 10512675. 
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