NME3

Non-metastatic cells 3, protein expressed in
PDB rendering based on 1zs6.
Available structures PDB 1zs6
Identifiers
Symbols	NME3; DR-nm23; KIAA0516; NDPK-C; NDPKC; NM23-H3; NM23H3; c371H6.2
External IDs	OMIM: 601817 MGI: 1930182 HomoloGene: 20562 GeneCards: NME3 Gene
EC number	2.7.4.6
Gene Ontology Molecular function • nucleotide binding • nucleoside diphosphate kinase activity • ATP binding • kinase activity • transferase activity • metal ion binding Cellular component • mitochondrion Biological process • GTP biosynthetic process • UTP biosynthetic process • CTP biosynthetic process • apoptosis • induction of apoptosis • nucleotide metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4832	79059
Ensembl	ENSG00000103024	ENSMUSG00000073435
UniProt	Q13232	Q9CWA5
RefSeq (mRNA)	NM_002513.2	NM_019730.2
RefSeq (protein)	NP_002504.2	NP_062704.2
Location (UCSC)	Chr 16: 1.82 – 1.82 Mb	Chr 17: 25.03 – 25.03 Mb
PubMed search	[1]	[2]

Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene.^[1][2]

Interactions

NME3 has been shown to interact with NME1^[3][4] and NME2.^[5][4]

References

1. ^ Martinez R, Venturelli D, Perrotti D, Veronese ML, Kastury K, Druck T, Huebner K, Calabretta B (Apr 1997). "Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family". Cancer Res 57 (6): 1180–7. PMID 9067290. 
2. ^ "Entrez Gene: NME3 non-metastatic cells 3, protein expressed in". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4832. 
3. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
4. ^ ^{a b} Negroni, A; Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (Sep. 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. (ENGLAND) 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. ISSN 1350-9047. PMID 11042679. 
5. ^ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (Sep. 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070. 

Further reading

• Venturelli D, Martinez R, Melotti P et al. (1995). "Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7435–9. doi:10.1073/pnas.92.16.7435. PMC 41354. PMID 7638209. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41354. 
• Negroni A, Venturelli D, Tanno B et al. (2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679. 
• Daniels RJ, Peden JF, Lloyd C et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Sheffler DJ, Kroeze WK, Garcia BG et al. (2006). "p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling". Proc. Natl. Acad. Sci. U.S.A. 103 (12): 4717–22. doi:10.1073/pnas.0600585103. PMC 1450237. PMID 16537434. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1450237. 
• Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
• Carinci F, Arcelli D, Lo Muzio L et al. (2007). "Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma". Translational research : the journal of laboratory and clinical medicine 150 (4): 233–45. doi:10.1016/j.trsl.2007.03.011. PMID 17900511.