NME2

Non-metastatic cells 2, protein (NM23B) expressed in
PDB rendering based on 1be4.
Available structures PDB 1NSK, 1NUE, 3BBB, 3BBC, 3BBF
Identifiers
Symbols	NME2; MGC111212; MGC2212; NDKB; NDPK-B; NDPKB; NM23-H2; NM23B; PUF
External IDs	OMIM: 156491 MGI: 97356 HomoloGene: 39553 GeneCards: NME2 Gene
Gene Ontology Molecular function • nucleotide binding • DNA binding • sequence-specific DNA binding transcription factor activity • nucleoside diphosphate kinase activity • protein histidine kinase activity • protein binding • ATP binding • kinase activity • transferase activity • metal ion binding Cellular component • ruffle • nucleus • cytoplasm • cytosol • lamellipodium Biological process • nucleoside diphosphate phosphorylation • GTP biosynthetic process • UTP biosynthetic process • CTP biosynthetic process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • cell adhesion • nucleotide metabolic process • nucleoside triphosphate biosynthetic process • nucleobase, nucleoside and nucleotide interconversion • negative regulation of apoptosis • positive regulation of keratinocyte differentiation • regulation of epidermis development • positive regulation of epithelial cell proliferation • nucleobase, nucleoside and nucleotide metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4831	18103
Ensembl	n/a	ENSMUSG00000020857
UniProt	P22392	Q5NC82
RefSeq (mRNA)	NM_001018137.2	NM_001077529
RefSeq (protein)	NP_001018147.1	NP_001070997
Location (UCSC)	n/a	Chr 11: 93.77 – 93.77 Mb
PubMed search	[1]	[2]

Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene.^[1][2]

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.^[2]

Interactions

NME2 has been shown to interact with NME3^[3][4] and HERC5.^[5]

References

1. ^ Stahl JA, Leone A, Rosengard AM, Porter L, King CR, Steeg PS (Feb 1991). "Identification of a second human nm23 gene, nm23-H2". Cancer Res 51 (1): 445–9. PMID 1988104. 
2. ^ ^{a b} "Entrez Gene: NME2 non-metastatic cells 2, protein (NM23B) expressed in". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4831. 
3. ^ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (Sep. 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070. 
4. ^ Negroni, A; Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (Sep. 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. (ENGLAND) 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. ISSN 1350-9047. PMID 11042679. 
5. ^ Hochrainer, K; Kroismayr R, Baranyi U, Binder B R, Lipp J (Jul. 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell. Mol. Life Sci. (Switzerland) 65 (13): 2105–17. doi:10.1007/s00018-008-8148-5. ISSN 1420-682X. PMID 18535780. 

Further reading

• Thakur RK, Kumar P, Halder K, Verma A, Kar A, Parent JL, Basundra R, Kumar A, Chowdhury S. (2009). "Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression". Nucleic Acids Res. 37 (1): 172–83. doi:10.1093/nar/gkn919. PMC 2615625. PMID 19033359. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2615625. 
• Gilles AM, Presecan E, Vonica A, Lascu I (1991). "Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme.". J. Biol. Chem. 266 (14): 8784–9. PMID 1851158. 
• Rosengard AM, Krutzsch HC, Shearn A, et al. (1989). "Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development.". Nature 342 (6246): 177–80. doi:10.1038/342177a0. PMID 2509941. 
• Webb PA, Perisic O, Mendola CE, et al. (1995). "The crystal structure of a human nucleoside diphosphate kinase, NM23-H2.". J. Mol. Biol. 251 (4): 574–87. doi:10.1006/jmbi.1995.0457. PMID 7658474. 
• Chandrasekharappa SC, Gross LA, King SE, Collins FS (1993). "The human NME2 gene lies within 18kb of NME1 in chromosome 17.". Genes Chromosomes Cancer 6 (4): 245–8. doi:10.1002/gcc.2870060411. PMID 7685630. 
• Ji L, Arcinas M, Boxer LM (1995). "The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma.". J. Biol. Chem. 270 (22): 13392–8. doi:10.1074/jbc.270.22.13392. PMID 7768941. 
• MacDonald NJ, De la Rosa A, Benedict MA, et al. (1994). "A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential.". J. Biol. Chem. 268 (34): 25780–9. PMID 8245015. 
• Backer JM, Mendola CE, Kovesdi I, et al. (1993). "Chromosomal localization and nucleoside diphosphate kinase activity of human metastasis-suppressor genes NM23-1 and NM23-2.". Oncogene 8 (2): 497–502. PMID 8381224. 
• Postel EH, Berberich SJ, Flint SJ, Ferrone CA (1993). "Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis.". Science 261 (5120): 478–80. doi:10.1126/science.8392752. PMID 8392752. 
• Kelsell DP, Black DM, Solomon E, Spurr NK (1993). "Localization of a second NM23 gene, NME2, to chromosome 17q21-q22.". Genomics 17 (2): 522–4. doi:10.1006/geno.1993.1362. PMID 8406509. 
• Engel M, Véron M, Theisinger B, et al. (1996). "A novel serine/threonine-specific protein phosphotransferase activity of Nm23/nucleoside-diphosphate kinase.". Eur. J. Biochem. 234 (1): 200–7. doi:10.1111/j.1432-1033.1995.200_c.x. PMID 8529641. 
• Guignard F, Markert M (1996). "The nucleoside diphosphate kinase of human neutrophils.". Biochem. J. 316 ( Pt 1): 233–8. PMC 1217327. PMID 8645210. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1217327. 
• Moréra S, Lacombe ML, Xu Y, et al. (1996). "X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution.". Structure 3 (12): 1307–14. doi:10.1016/S0969-2126(01)00268-4. PMID 8747457. 
• Paravicini G, Steinmayr M, André E, Becker-André M (1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily.". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107. 
• Nosaka K, Kawahara M, Masuda M, et al. (1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres.". Biochem. Biophys. Res. Commun. 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. PMID 9480811. 
• Pinon VP, Millot G, Munier A, et al. (1999). "Cytoskeletal association of the A and B nucleoside diphosphate kinases of interphasic but not mitotic human carcinoma cell lines: specific nuclear localization of the B subunit.". Exp. Cell Res. 246 (2): 355–67. doi:10.1006/excr.1998.4318. PMID 9925751. 
• Negroni A, Venturelli D, Tanno B, et al. (2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis.". Cell Death Differ. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679. 
• Roymans D, Willems R, Vissenberg K, et al. (2000). "Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma.". Exp. Cell Res. 261 (1): 127–38. doi:10.1006/excr.2000.5037. PMID 11082283. 
• Baillat G, Gaillard S, Castets F, Monneron A (2002). "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I.". J. Biol. Chem. 277 (21): 18961–6. doi:10.1074/jbc.M108818200. PMID 11872741. 
• Fournier HN, Dupé-Manet S, Bouvard D, et al. (2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement.". J. Biol. Chem. 277 (23): 20895–902. doi:10.1074/jbc.M200200200. PMID 11919189. 

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