DYNLT3

Dynein, light chain, Tctex-type 3
Identifiers
Symbols	DYNLT3; RP3; TCTE1L; TCTEX1L
External IDs	OMIM: 300302 MGI: 1914367 HomoloGene: 21304 GeneCards: DYNLT3 Gene
Gene Ontology Molecular function • motor activity • protein binding • identical protein binding Cellular component • kinetochore • condensed chromosome kinetochore • nucleus • chromosome • cytoplasm • cytoskeleton • cytoplasmic dynein complex • microtubule • plasma membrane Biological process • transport • cell cycle • mitosis • regulation of mitotic cell cycle • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6990	67117
Ensembl	ENSG00000165169	ENSMUSG00000031176
UniProt	P51808	Q542J7
RefSeq (mRNA)	NM_006520	NM_025975.5
RefSeq (protein)	NP_006511	NP_080251.3
Location (UCSC)	Chr X: 37.7 – 37.71 Mb	Chr X: 9.23 – 9.24 Mb
PubMed search	[1]	[2]

Dynein, light chain, Tctex-type 3, also known as DYNLT3, is a protein which in humans is encoded by the DYNLT3 gene.^[1][2]

Function

DYNLT3 is a member of the dynein motor protein family. DYNLT3 binds to BUB3, a spindle checkpoint protein is present on kinetochores at prometaphase.^[3] DYNLT3 can also function as a transcription regulator of Bcl-2 gene through binding to SATB1 in a dynein-independent manner.^[4]

Interactions

DYNLT3 has been shown to interact with VDAC1.^[5]

References

1. ^ "Entrez Gene: DYNLT3 dynein, light chain, Tctex-type 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6990. 
2. ^ Roux AF, Rommens J, McDowell C, Anson-Cartwright L, Bell S, Schappert K, Fishman GA, Musarella M (February 1994). "Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex". Hum. Mol. Genet. 3 (2): 257–63. doi:10.1093/hmg/3.2.257. PMID 8004092. 
3. ^ Lo KW, Kogoy JM, Pfister KK (April 2007). "The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3". J. Biol. Chem. 282 (15): 11205–12. doi:10.1074/jbc.M611279200. PMID 17289665. 
4. ^ Yeh TY, Chuang JZ, Sung CH (August 2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway". J. Cell. Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286. 
5. ^ Schwarzer, Christian; Barnikol-Watanabe Shitsu, Thinnes Friedrich P, Hilschmann Norbert (Sep. 2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. (England) 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. ISSN 1357-2725. PMID 12009301. 

Further reading

• Roux AF, Rommens J, McDowell C, et al. (1994). "Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex.". Hum. Mol. Genet. 3 (2): 257–63. doi:10.1093/hmg/3.2.257. PMID 8004092. 
• Bauch A, Campbell KS, Reth M (1998). "Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta.". Eur. J. Immunol. 28 (7): 2167–77. doi:10.1002/(SICI)1521-4141(199807)28:07<2167::AID-IMMU2167>3.0.CO;2-L. PMID 9692886. 
• Mueller S, Cao X, Welker R, Wimmer E (2002). "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.". J. Biol. Chem. 277 (10): 7897–904. doi:10.1074/jbc.M111937200. PMID 11751937. 
• Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74.". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. PMID 12009301. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Yeh TY, Chuang JZ, Sung CH (2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway.". J. Cell. Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• O'Rourke SM, Dorfman MD, Carter JC, Bowerman B (2007). "Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants.". PLoS Genet. 3 (8): e128. doi:10.1371/journal.pgen.0030128. PMC 1937013. PMID 17676955. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1937013.