SATB1

SATB homeobox 1, also known as SATB1, is a human gene.cite web | title = Entrez Gene: SATB1 SATB homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6304| accessdate = ]

SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation. Recent studies have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli. At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of IFNgamma treatment on chromatin loop architecture of the MHC class-I locus and altered expression of genes within the locus.

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References

Further reading

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*cite journal | author=Dickinson LA, Joh T, Kohwi Y, Kohwi-Shigematsu T |title=A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. |journal=Cell |volume=70 |issue= 4 |pages= 631–45 |year= 1992 |pmid= 1505028 |doi=
*cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, "et al." |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457
*cite journal | author=Nakagomi K, Kohwi Y, Dickinson LA, Kohwi-Shigematsu T |title=A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1. |journal=Mol. Cell. Biol. |volume=14 |issue= 3 |pages= 1852–60 |year= 1994 |pmid= 8114718 |doi=
*cite journal | author=Xu L, Deng HX, Xia JH, "et al." |title=Assignment of SATB1 to human chromosome band 3p23 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 205–6 |year= 1997 |pmid= 9284917 |doi=
*cite journal | author=Reddy PH, Stockburger E, Gillevet P, Tagle DA |title=Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. |journal=Genomics |volume=46 |issue= 2 |pages= 174–82 |year= 1998 |pmid= 9417904 |doi= 10.1006/geno.1997.5044
*cite journal | author=Escalier D, Allenet B, Badrichani A, Garchon HJ |title=High level expression of the Xlr nuclear protein in immature thymocytes and colocalization with the matrix-associated region-binding SATB1 protein. |journal=J. Immunol. |volume=162 |issue= 1 |pages= 292–8 |year= 1999 |pmid= 9886398 |doi=
*cite journal | author=Liu J, Barnett A, Neufeld EJ, Dudley JP |title=Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4918–26 |year= 1999 |pmid= 10373541 |doi=
*cite journal | author=Galande S, Dickinson LA, Mian IS, "et al." |title=SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis. |journal=Mol. Cell. Biol. |volume=21 |issue= 16 |pages= 5591–604 |year= 2001 |pmid= 11463840 |doi= 10.1128/MCB.21.16.5591-5604.2001
*cite journal | author=Kieffer LJ, Greally JM, Landres I, "et al." |title=Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3. |journal=J. Immunol. |volume=168 |issue= 8 |pages= 3915–22 |year= 2002 |pmid= 11937547 |doi=
*cite journal | author=Durrin LK, Krontiris TG |title=The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11. |journal=Genomics |volume=79 |issue= 6 |pages= 809–17 |year= 2002 |pmid= 12036295 |doi= 10.1006/geno.2002.6772
*cite journal | author=Yasui D, Miyano M, Cai S, "et al." |title=SATB1 targets chromatin remodelling to regulate genes over long distances. |journal=Nature |volume=419 |issue= 6907 |pages= 641–5 |year= 2002 |pmid= 12374985 |doi= 10.1038/nature01084
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cai S, Han HJ, Kohwi-Shigematsu T |title=Tissue-specific nuclear architecture and gene expression regulated by SATB1. |journal=Nat. Genet. |volume=34 |issue= 1 |pages= 42–51 |year= 2003 |pmid= 12692553 |doi= 10.1038/ng1146
*cite journal | author=Fujii Y, Kumatori A, Nakamura M |title=SATB1 makes a complex with p300 and represses gp91(phox) promoter activity. |journal=Microbiol. Immunol. |volume=47 |issue= 10 |pages= 803–11 |year= 2004 |pmid= 14605447 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gocke CB, Yu H, Kang J |title=Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 5004–12 |year= 2005 |pmid= 15561718 |doi= 10.1074/jbc.M411718200
*cite journal | author=Wen J, Huang S, Rogers H, "et al." |title=SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression. |journal=Blood |volume=105 |issue= 8 |pages= 3330–9 |year= 2005 |pmid= 15618465 |doi= 10.1182/blood-2004-08-2988
*cite journal | author=Seo J, Lozano MM, Dudley JP |title=Nuclear matrix binding regulates SATB1-mediated transcriptional repression. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 24600–9 |year= 2005 |pmid= 15851481 |doi= 10.1074/jbc.M414076200
*cite journal | author=Nakayama Y, Mian IS, Kohwi-Shigematsu T, Ogawa T |title=A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage. |journal=Cell Cycle |volume=4 |issue= 8 |pages= 1099–106 |year= 2006 |pmid= 15970696 |doi=
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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