POLR2J2

DNA directed RNA polymerase II polypeptide J-related gene, also known as POLR2J2, is a human gene.cite web | title = Entrez Gene: POLR2J2 DNA directed RNA polymerase II polypeptide J-related gene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=246721| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.cite web | title = Entrez Gene: POLR2J2 DNA directed RNA polymerase II polypeptide J-related gene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=246721| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Shpakovskii DG, Shematorova EK, Shpakovskii GV |title=Human PMS2 gene family: origin, molecular evolution, and biological implications. |journal=Dokl. Biochem. Biophys. |volume=408 |issue= |pages= 175–9 |year= 2006 |pmid= 16913423 |doi=
*cite journal | author=Benga WJ, Grandemange S, Shpakovski GV, "et al." |title=Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II. |journal=Nucleic Acids Res. |volume=33 |issue= 11 |pages= 3582–90 |year= 2005 |pmid= 15987790 |doi= 10.1093/nar/gki672
*cite journal | author=Shpakovskiĭ DG, Shematorova EK, Shpakovskiĭ GV |title= [New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family] |journal=Bioorg. Khim. |volume=30 |issue= 6 |pages= 621–5 |year= 2005 |pmid= 15586814 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Durrin LK, Krontiris TG |title=The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11. |journal=Genomics |volume=79 |issue= 6 |pages= 809–17 |year= 2002 |pmid= 12036295 |doi= 10.1006/geno.2002.6772
*cite journal | author=Grandemange S, Schaller S, Yamano S, "et al." |title=A human RNA polymerase II subunit is encoded by a recently generated multigene family. |journal=BMC Mol. Biol. |volume=2 |issue= |pages= 14 |year= 2003 |pmid= 11747469 |doi=
*cite journal | author=Cramer P, Bushnell DA, Fu J, "et al." |title=Architecture of RNA polymerase II and implications for the transcription mechanism. |journal=Science |volume=288 |issue= 5466 |pages= 640–9 |year= 2000 |pmid= 10784442 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=

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