CHD3

Chromodomain helicase DNA binding protein 3, also known as CHD3, is a human gene.cite web | title = Entrez Gene: CHD3 chromodomain helicase DNA binding protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1107| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.cite web | title = Entrez Gene: CHD3 chromodomain helicase DNA binding protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1107| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bowen NJ, Fujita N, Kajita M, Wade PA |title=Mi-2/NuRD: multiple complexes for many purposes. |journal=Biochim. Biophys. Acta |volume=1677 |issue= 1-3 |pages= 52–7 |year= 2004 |pmid= 15020045 |doi= 10.1016/j.bbaexp.2003.10.010
*cite journal | author=Gieser L, Swaroop A |title=Expressed sequence tags and chromosomal localization of cDNA clones from a subtracted retinal pigment epithelium library. |journal=Genomics |volume=13 |issue= 3 |pages= 873–6 |year= 1992 |pmid= 1639417 |doi=
*cite journal | author=Ge Q, Nilasena DS, O'Brien CA, "et al." |title=Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen. |journal=J. Clin. Invest. |volume=96 |issue= 4 |pages= 1730–7 |year= 1995 |pmid= 7560064 |doi=
*cite journal | author=Seelig HP, Moosbrugger I, Ehrfeld H, "et al." |title=The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation. |journal=Arthritis Rheum. |volume=38 |issue= 10 |pages= 1389–99 |year= 1995 |pmid= 7575689 |doi=
*cite journal | author=Seelig HP, Renz M, Targoff IN, "et al." |title=Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen. |journal=Arthritis Rheum. |volume=39 |issue= 10 |pages= 1769–71 |year= 1996 |pmid= 8843877 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Woodage T, Basrai MA, Baxevanis AD, "et al." |title=Characterization of the CHD family of proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11472–7 |year= 1997 |pmid= 9326634 |doi=
*cite journal | author=Aubry F, Mattéi MG, Galibert F |title=Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family. |journal=Eur. J. Biochem. |volume=254 |issue= 3 |pages= 558–64 |year= 1998 |pmid= 9688266 |doi=
*cite journal | author=Tong JK, Hassig CA, Schnitzler GR, "et al." |title=Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. |journal=Nature |volume=395 |issue= 6705 |pages= 917–21 |year= 1998 |pmid= 9804427 |doi= 10.1038/27699
*cite journal | author=Kleiderlein JJ, Nisson PE, Jessee J, "et al." |title=CCG repeats in cDNAs from human brain. |journal=Hum. Genet. |volume=103 |issue= 6 |pages= 666–73 |year= 1999 |pmid= 9921901 |doi=
*cite journal | author=Kim J, Sif S, Jones B, "et al." |title=Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. |journal=Immunity |volume=10 |issue= 3 |pages= 345–55 |year= 1999 |pmid= 10204490 |doi=
*cite journal | author=Wade PA, Gegonne A, Jones PL, "et al." |title=Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. |journal=Nat. Genet. |volume=23 |issue= 1 |pages= 62–6 |year= 1999 |pmid= 10471500 |doi= 10.1038/12664
*cite journal | author=Cousin P, Billotte J, Chaubert P, Shaw P |title=Physical map of 17p13 and the genes adjacent to p53. |journal=Genomics |volume=63 |issue= 1 |pages= 60–8 |year= 2000 |pmid= 10662545 |doi= 10.1006/geno.1999.6062
*cite journal | author=Minty A, Dumont X, Kaghad M, Caput D |title=Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif. |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36316–23 |year= 2000 |pmid= 10961991 |doi= 10.1074/jbc.M004293200
*cite journal | author=Schultz DC, Friedman JR, Rauscher FJ |title=Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. |journal=Genes Dev. |volume=15 |issue= 4 |pages= 428–43 |year= 2001 |pmid= 11230151 |doi= 10.1101/gad.869501
*cite journal | author=Yasui D, Miyano M, Cai S, "et al." |title=SATB1 targets chromatin remodelling to regulate genes over long distances. |journal=Nature |volume=419 |issue= 6907 |pages= 641–5 |year= 2002 |pmid= 12374985 |doi= 10.1038/nature01084
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lemos TA, Passos DO, Nery FC, Kobarg J |title=Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. |journal=FEBS Lett. |volume=533 |issue= 1-3 |pages= 14–20 |year= 2003 |pmid= 12505151 |doi=
*cite journal | author=Fujita N, Jaye DL, Kajita M, "et al." |title=MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. |journal=Cell |volume=113 |issue= 2 |pages= 207–19 |year= 2003 |pmid= 12705869 |doi=
*cite journal | author=Lee BH, Yoshimatsu K, Maeda A, "et al." |title=Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules. |journal=Virus Res. |volume=98 |issue= 1 |pages= 83–91 |year= 2004 |pmid= 14609633 |doi=

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