DYNC1H1

Dynein, cytoplasmic 1, heavy chain 1
Rendering based on PDB 2BOR.
Available structures PDB 2BOR, 2BOT
Identifiers
Symbols	DYNC1H1; DHC1; DHC1a; DKFZp686P2245; DNCH1; DNCL; DNECL; DYHC; Dnchc1; HL-3; KIAA0325; p22
External IDs	OMIM: 600112 MGI: 103147 HomoloGene: 1053 GeneCards: DYNC1H1 Gene
Gene Ontology Molecular function • nucleotide binding • microtubule motor activity • protein binding • ATP binding • ATPase activity, coupled Cellular component • cytoplasm • Golgi apparatus • centrosome • cytosol • cytoskeleton • cytoplasmic dynein complex • microtubule Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • transport • microtubule-based movement • mitotic spindle organization • cytoplasmic mRNA processing body assembly • stress granule assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1778	13424
Ensembl	ENSG00000197102	ENSMUSG00000018707
UniProt	Q14204	O08821
RefSeq (mRNA)	NM_001376	NM_030238.2
RefSeq (protein)	NP_001367	NP_084514.2
Location (UCSC)	Chr 14: 102.43 – 102.52 Mb	Chr 12: 111.84 – 111.91 Mb
PubMed search	[1]	[2]

Cytoplasmic dynein 1 heavy chain 1 is a protein that in humans is encoded by the DYNC1H1 gene.^[1][2][3]

Interactions

DYNC1H1 has been shown to interact with PAFAH1B1^[4] and CDC5L.^[5]

References

1. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2171247. 
2. ^ Vaisberg EA, Grissom PM, McIntosh JR (Aug 1996). "Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles". J Cell Biol 133 (4): 831–42. doi:10.1083/jcb.133.4.831. PMC 2120833. PMID 8666668. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120833. 
3. ^ "Entrez Gene: DYNC1H1 dynein, cytoplasmic 1, heavy chain 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1778. 
4. ^ Tai, Chin-Yin; Dujardin Denis L, Faulkner Nicole E, Vallee Richard B (Mar. 2002). "Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function". J. Cell Biol. (United States) 156 (6): 959–68. doi:10.1083/jcb.200109046. ISSN 0021-9525. PMC 2173479. PMID 11889140. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173479. 
5. ^ Ajuh, P; Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (Dec. 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305846. 

Further reading

• Narayan D, Desai T, Banks A, et al. (1995). "Localization of the human cytoplasmic dynein heavy chain (DNECL) to 14qter by fluorescence in situ hybridization.". Genomics 22 (3): 660–1. doi:10.1006/geno.1994.1447. PMID 8001984. 
• Vaisberg EA, Koonce MP, McIntosh JR (1993). "Cytoplasmic dynein plays a role in mammalian mitotic spindle formation.". J. Cell Biol. 123 (4): 849–58. doi:10.1083/jcb.123.4.849. PMC 2200153. PMID 8227145. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2200153. 
• Vaughan KT, Mikami A, Paschal BM, et al. (1997). "Multiple mouse chromosomal loci for dynein-based motility.". Genomics 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841. 
• Neesen J, Koehler MR, Kirschner R, et al. (1997). "Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.". Gene 200 (1-2): 193–202. doi:10.1016/S0378-1119(97)00417-4. PMID 9373155. 
• Byers HR, Yaar M, Eller MS, et al. (2000). "Role of cytoplasmic dynein in melanosome transport in human melanocytes.". J. Invest. Dermatol. 114 (5): 990–7. doi:10.1046/j.1523-1747.2000.00957.x. PMID 10771482. 
• Habermann A, Schroer TA, Griffiths G, Burkhardt JK (2001). "Immunolocalization of cytoplasmic dynein and dynactin subunits in cultured macrophages: enrichment on early endocytic organelles.". J. Cell. Sci. 114 (Pt 1): 229–240. PMID 11112706. 
• Sasaki S, Shionoya A, Ishida M, et al. (2001). "A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system.". Neuron 28 (3): 681–96. doi:10.1016/S0896-6273(00)00146-X. PMID 11163259. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Payne C, Rawe V, Ramalho-Santos J, et al. (2004). "Preferentially localized dynein and perinuclear dynactin associate with nuclear pore complex proteins to mediate genomic union during mammalian fertilization.". J. Cell. Sci. 116 (Pt 23): 4727–38. doi:10.1242/jcs.00784. PMID 14600259. 
• Byers HR, Maheshwary S, Amodeo DM, Dykstra SG (2003). "Role of cytoplasmic dynein in perinuclear aggregation of phagocytosed melanosomes and supranuclear melanin cap formation in human keratinocytes.". J. Invest. Dermatol. 121 (4): 813–20. doi:10.1046/j.1523-1747.2003.12481.x. PMID 14632200. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. 
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148. 
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.