TPM1

Tropomyosin 1 (alpha), also known as TPM1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.cite web | title = Entrez Gene: TPM1 tropomyosin 1 (alpha)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7168| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lees-Miller JP, Helfman DM |title=The molecular basis for tropomyosin isoform diversity. |journal=Bioessays |volume=13 |issue= 9 |pages= 429–37 |year= 1992 |pmid= 1796905 |doi= 10.1002/bies.950130902
*cite journal | author=Balvay L, Fiszman MY |title= [Analysis of the diversity of tropomyosin isoforms] |journal=C. R. Seances Soc. Biol. Fil. |volume=188 |issue= 5-6 |pages= 527–40 |year= 1995 |pmid= 7780795 |doi=
*cite journal | author=Gunning P, Weinberger R, Jeffrey P |title=Actin and tropomyosin isoforms in morphogenesis. |journal=Anat. Embryol. |volume=195 |issue= 4 |pages= 311–5 |year= 1997 |pmid= 9108196 |doi=
*cite journal | author=Perry SV |title=Vertebrate tropomyosin: distribution, properties and function. |journal=J. Muscle Res. Cell. Motil. |volume=22 |issue= 1 |pages= 5–49 |year= 2002 |pmid= 11563548 |doi=
*cite journal | author=Perry SV |title=What is the role of tropomyosin in the regulation of muscle contraction? |journal=J. Muscle Res. Cell. Motil. |volume=24 |issue= 8 |pages= 593–6 |year= 2004 |pmid= 14870975 |doi=
*cite journal | author=Jääskeläinen P, Miettinen R, Kärkkäinen P, "et al." |title=Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes. |journal=Ann. Med. |volume=36 |issue= 1 |pages= 23–32 |year= 2004 |pmid= 15000344 |doi=
*cite journal | author=Mak A, Smillie LB, Bárány M |title=Specific phosphorylation at serine-283 of alpha tropomyosin from frog skeletal and rabbit skeletal and cardiac muscle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=75 |issue= 8 |pages= 3588–92 |year= 1978 |pmid= 278975 |doi=
*cite journal | author=Höner B, Shoeman RL, Traub P |title=Degradation of cytoskeletal proteins by the human immunodeficiency virus type 1 protease. |journal=Cell Biol. Int. Rep. |volume=16 |issue= 7 |pages= 603–12 |year= 1992 |pmid= 1516138 |doi=
*cite journal | author=Chevray PM, Nathans D |title=Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 13 |pages= 5789–93 |year= 1992 |pmid= 1631061 |doi=
*cite journal | author=Shoeman RL, Kesselmier C, Mothes E, "et al." |title=Non-viral cellular substrates for human immunodeficiency virus type 1 protease. |journal=FEBS Lett. |volume=278 |issue= 2 |pages= 199–203 |year= 1991 |pmid= 1991513 |doi=
*cite journal | author=Cho YJ, Liu J, Hitchcock-DeGregori SE |title=The amino terminus of muscle tropomyosin is a major determinant for function. |journal=J. Biol. Chem. |volume=265 |issue= 1 |pages= 538–45 |year= 1990 |pmid= 2136742 |doi=
*cite journal | author=Colote S, Widada JS, Ferraz C, "et al." |title=Evolution of tropomyosin functional domains: differential splicing and genomic constraints. |journal=J. Mol. Evol. |volume=27 |issue= 3 |pages= 228–35 |year= 1988 |pmid= 3138425 |doi=
*cite journal | author=Lin CS, Leavitt J |title=Cloning and characterization of a cDNA encoding transformation-sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts. |journal=Mol. Cell. Biol. |volume=8 |issue= 1 |pages= 160–8 |year= 1988 |pmid= 3336357 |doi=
*cite journal | author=MacLeod AR, Gooding C |title=Human hTM alpha gene: expression in muscle and nonmuscle tissue. |journal=Mol. Cell. Biol. |volume=8 |issue= 1 |pages= 433–40 |year= 1988 |pmid= 3336363 |doi=
*cite journal | author=Mische SM, Manjula BN, Fischetti VA |title=Relation of streptococcal M protein with human and rabbit tropomyosin: the complete amino acid sequence of human cardiac alpha tropomyosin, a highly conserved contractile protein. |journal=Biochem. Biophys. Res. Commun. |volume=142 |issue= 3 |pages= 813–8 |year= 1987 |pmid= 3548719 |doi=
*cite journal | author=Heeley DH, Golosinska K, Smillie LB |title=The effects of troponin T fragments T1 and T2 on the binding of nonpolymerizable tropomyosin to F-actin in the presence and absence of troponin I and troponin C. |journal=J. Biol. Chem. |volume=262 |issue= 21 |pages= 9971–8 |year= 1987 |pmid= 3611073 |doi=
*cite journal | author=Brown HR, Schachat FH |title=Renaturation of skeletal muscle tropomyosin: implications for in vivo assembly. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 8 |pages= 2359–63 |year= 1985 |pmid= 3857586 |doi=
*cite journal | author=Tanokura M, Ohtsuki I |title=Interactions among chymotryptic troponin T subfragments, tropomyosin, troponin I and troponin C. |journal=J. Biochem. |volume=95 |issue= 5 |pages= 1417–21 |year= 1984 |pmid= 6746613 |doi=
*cite journal | author=Pearlstone JR, Smillie LB |title=Effects of troponin-I plus-C on the binding of troponin-T and its fragments to alpha-tropomyosin. Ca2+ sensitivity and cooperativity. |journal=J. Biol. Chem. |volume=258 |issue= 4 |pages= 2534–42 |year= 1983 |pmid= 6822572 |doi=

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