D-2-hydroxy-acid dehydrogenase

D-2-hydroxy-acid dehydrogenase
Identifiers
EC number	1.1.99.6
CAS number	9028-83-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) is an enzyme that catalyzes the chemical reaction

(R)-lactate + acceptor $\rightleftharpoons$ pyruvate + reduced acceptor

Thus, the two substrates of this enzyme are (R)-lactate and acceptor, whereas its two products are pyruvate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (R)-2-hydroxy-acid:acceptor 2-oxidoreductase. Other names in common use include D-2-hydroxy acid dehydrogenase, and (R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase. It has 2 cofactors: FAD, and Zinc.

References

• GREGOLIN C, SINGER TP, KEARNEY EB, BOERI E (1961). "The formation and enzymatic properties of the various lactic dehydrogenases of yeast". Ann. N. Y. Acad. Sci. 94 (3): 780–97. doi:10.1111/j.1749-6632.1961.tb35573.x. PMID 13901630. 
• Nygaard AP (1961). "D(-)-Lactate cytochrome c reductase, a flavoprotein from yeast". J. Biol. Chem. 236: 920–925. 
• Tubbs PK and Greville GD (1959). "Dehydrogenation of D-lactate by a soluble enzyme from kidney mitochondria". Biochim. Biophys. Acta 34: 290–291. doi:10.1016/0006-3002(59)90276-8. PMID 13839714. 

This EC 1.1 enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: EC 1.1.99 Flavin enzymes Zinc enzymes Enzymes of unknown structure Protein families EC 1.1 stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу TPM1 D-arabinono-1,4-lactone oxidase Look at other dictionaries: (S)-2-hydroxy-fatty-acid dehydrogenase — In enzymology, a (S) 2 hydroxy fatty acid dehydrogenase (EC number|1.1.1.99) is an enzyme that catalyzes the chemical reaction:(S) 2 hydroxystearate + NAD+ ightleftharpoons 2 oxostearate + NADH + H+Thus, the two substrates of this enzyme are (S)… …   Wikipedia (R)-2-hydroxy-fatty-acid dehydrogenase — In enzymology, a (R) 2 hydroxy fatty acid dehydrogenase (EC number|1.1.1.98) is an enzyme that catalyzes the chemical reaction:(R) 2 hydroxystearate + NAD+ ightleftharpoons 2 oxostearate + NADH + H+Thus, the two substrates of this enzyme are (R)… …   Wikipedia 3-hydroxyacyl-CoA dehydrogenase — In enzymology, a 3 hydroxyacyl CoA dehydrogenase (EC number|1.1.1.35) is an enzyme that catalyzes the chemical reaction:(S) 3 hydroxyacyl CoA + NAD+ ightleftharpoons 3 oxoacyl CoA + NADH + H+Thus, the two substrates of this enzyme are (S) 3… …   Wikipedia (R)-2-hydroxyacid dehydrogenase — In enzymology, a (R) 2 hydroxyacid dehydrogenase (EC number|1.1.1.272) is an enzyme that catalyzes the chemical reaction:(2R) 3 sulfolactate + NAD(P)+ ightleftharpoons 3 sulfopyruvate + NAD(P)H + H+The 3 substrates of this enzyme are (2R) 3… …   Wikipedia Amino acid — This article is about the class of chemicals. For the structures and properties of the standard proteinogenic amino acids, see Proteinogenic amino acid. The generic structure of an alpha amino acid in its unionized form …   Wikipedia 15-hydroxyprostaglandin-D dehydrogenase (NADP+) — In enzymology, a 15 hydroxyprostaglandin D dehydrogenase (NADP+) (EC number|1.1.1.196) is an enzyme that catalyzes the chemical reaction:(5Z,13E) (15S) 9alpha,15 dihydroxy 11 oxoprosta 5,13 dienoate + NADP+ ightleftharpoons (5Z,13E) 9alpha… …   Wikipedia Omega-hydroxydecanoate dehydrogenase — Identifiers EC number 1.1.1.66 CAS number 9028 65 3 …   Wikipedia 12alpha-hydroxysteroid dehydrogenase — In enzymology, a 12alpha hydroxysteroid dehydrogenase (EC number|1.1.1.176) is an enzyme that catalyzes the chemical reaction:3alpha,7alpha,12alpha trihydroxy 5beta cholanate + NADP+ ightleftharpoons 3alpha,7alpha dihydroxy 12 oxo 5beta cholanate …   Wikipedia Lactic acid — L Lactic acid …   Wikipedia L-gulonate 3-dehydrogenase — In enzymology, a L gulonate 3 dehydrogenase (EC number|1.1.1.45) is an enzyme that catalyzes the chemical reaction:L gulonate + NAD+ ightleftharpoons 3 dehydro L gulonate + NADH + H+Thus, the two substrates of this enzyme are L gulonate and NAD+ …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”