12alpha-hydroxysteroid dehydrogenase

12alpha-hydroxysteroid dehydrogenase

In enzymology, a 12alpha-hydroxysteroid dehydrogenase (EC number|1.1.1.176) is an enzyme that catalyzes the chemical reaction

:3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + NADP+ ightleftharpoons 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H+

Thus, the two substrates of this enzyme are 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate and NADP+, whereas its 3 products are 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 12alpha-hydroxysteroid:NADP+ 12-oxidoreductase. Other names in common use include 12alpha-hydroxy steroid dehydrogenase, 12alpha-hydroxy steroid dehydrogenase, NAD+-dependent 12alpha-hydroxysteroid dehydrogenase, and NADP+-12alpha-hydroxysteroid dehydrogenase. This enzyme is involved in a metabolic pathway that degrades bile acids into cholesterol.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|61642-40-8."

Gene Ontology (GO) codes


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  • 7alpha-hydroxysteroid dehydrogenase — In enzymology, a 7alpha hydroxysteroid dehydrogenase (EC number|1.1.1.159) is an enzyme that catalyzes the chemical reaction:3alpha,7alpha,12alpha trihydroxy 5beta cholanate + NAD+ ightleftharpoons 3alpha,12alpha dihydroxy 7 oxo 5beta cholanate + …   Wikipedia

  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

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