7alpha-hydroxysteroid dehydrogenase

In enzymology, a 7alpha-hydroxysteroid dehydrogenase (EC number|1.1.1.159) is an enzyme that catalyzes the chemical reaction

:3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + NAD⁺ $ightleftharpoons$ 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H⁺

Thus, the two substrates of this enzyme are 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate and NAD⁺, whereas its 3 products are 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7alpha-hydroxysteroid:NAD+ 7-oxidoreductase. Other names in common use include 7alpha-hydroxy steroid dehydrogenase, and 7alpha-HSDH.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1AHH, PDB link|1AHI, and PDB link|1FMC.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|39361-64-3."

Gene Ontology (GO) codes