HSD17B10

Hydroxysteroid (17-beta) dehydrogenase 10, also known as HSD17B10, is a human gene.cite web | title = Entrez Gene: HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3028| accessdate = ]

PBB_Summary
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summary_text = This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.cite web | title = Entrez Gene: HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3028| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yang SY, He XY, Schulz H |title=3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease. |journal=FEBS J. |volume=272 |issue= 19 |pages= 4874–83 |year= 2005 |pmid= 16176262 |doi= 10.1111/j.1742-4658.2005.04911.x
*cite journal | author=Yang SY, He XY, Miller D |title=HSD17B10: a gene involved in cognitive function through metabolism of isoleucine and neuroactive steroids. |journal=Mol. Genet. Metab. |volume=92 |issue= 1-2 |pages= 36–42 |year= 2007 |pmid= 17618155 |doi= 10.1016/j.ymgme.2007.06.001
*cite journal | author=Vredendaal PJ, van den Berg IE, Malingré HE, "et al." |title=Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence. |journal=Biochem. Biophys. Res. Commun. |volume=223 |issue= 3 |pages= 718–23 |year= 1996 |pmid= 8687463 |doi=
*cite journal | author=Furuta S, Kobayashi A, Miyazawa S, Hashimoto T |title=Cloning and expression of cDNA for a newly identified isozyme of bovine liver 3-hydroxyacyl-CoA dehydrogenase and its import into mitochondria. |journal=Biochim. Biophys. Acta |volume=1350 |issue= 3 |pages= 317–24 |year= 1997 |pmid= 9061028 |doi=
*cite journal | author=Yan SD, Fu J, Soto C, "et al." |title=An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease. |journal=Nature |volume=389 |issue= 6652 |pages= 689–95 |year= 1997 |pmid= 9338779 |doi= 10.1038/39522
*cite journal | author=He XY, Schulz H, Yang SY |title=A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease. |journal=J. Biol. Chem. |volume=273 |issue= 17 |pages= 10741–6 |year= 1998 |pmid= 9553139 |doi=
*cite journal | author=Miller AP, Willard HF |title=Chromosomal basis of X chromosome inactivation: identification of a multigene domain in Xp11.21-p11.22 that escapes X inactivation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8709–14 |year= 1998 |pmid= 9671743 |doi=
*cite journal | author=Sambamurti K, Lahiri DK |title=ERAB contains a putative noncleavable signal peptide. |journal=Biochem. Biophys. Res. Commun. |volume=249 |issue= 2 |pages= 546–9 |year= 1998 |pmid= 9712734 |doi= 10.1006/bbrc.1998.9178
*cite journal | author=Hansis C, Jähner D, Spiess AN, "et al." |title=The gene for the Alzheimer-associated beta-amyloid-binding protein (ERAB) is differentially expressed in the testicular Leydig cells of the azoospermic by w/w(v) mouse. |journal=Eur. J. Biochem. |volume=258 |issue= 1 |pages= 53–60 |year= 1998 |pmid= 9851691 |doi=
*cite journal | author=Yan SD, Shi Y, Zhu A, "et al." |title=Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity. |journal=J. Biol. Chem. |volume=274 |issue= 4 |pages= 2145–56 |year= 1999 |pmid= 9890977 |doi=
*cite journal | author=He XY, Merz G, Mehta P, "et al." |title=Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 15014–9 |year= 1999 |pmid= 10329704 |doi=
*cite journal | author=Oppermann UC, Salim S, Tjernberg LO, "et al." |title=Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease. |journal=FEBS Lett. |volume=451 |issue= 3 |pages= 238–42 |year= 1999 |pmid= 10371197 |doi=
*cite journal | author=He XY, Yang YZ, Schulz H, Yang SY |title=Intrinsic alcohol dehydrogenase and hydroxysteroid dehydrogenase activities of human mitochondrial short-chain L-3-hydroxyacyl-CoA dehydrogenase. |journal=Biochem. J. |volume=345 Pt 1 |issue= |pages= 139–43 |year= 2000 |pmid= 10600649 |doi=
*cite journal | author=Yang SY, He XY |title=Role of type 10 17beta-hydroxysteroid dehydrogenase in the pathogenesis of Alzheimer's disease. |journal=Adv. Exp. Med. Biol. |volume=487 |issue= |pages= 101–10 |year= 2001 |pmid= 11403151 |doi=
*cite journal | author=Frackowiak J, Mazur-Kolecka B, Kaczmarski W, Dickson D |title=Deposition of Alzheimer's vascular amyloid-beta is associated with decreased expression of brain L-3-hydroxyacyl-coenzyme A dehydrogenase (ERAB). |journal=Brain Res. |volume=907 |issue= 1-2 |pages= 44–53 |year= 2001 |pmid= 11430884 |doi=
*cite journal | author=He XY, Merz G, Yang YZ, "et al." |title=Characterization and localization of human type10 17beta-hydroxysteroid dehydrogenase. |journal=Eur. J. Biochem. |volume=268 |issue= 18 |pages= 4899–907 |year= 2001 |pmid= 11559359 |doi=
*cite journal | author=He XY, Wen GY, Merz G, "et al." |title=Abundant type 10 17 beta-hydroxysteroid dehydrogenase in the hippocampus of mouse Alzheimer's disease model. |journal=Brain Res. Mol. Brain Res. |volume=99 |issue= 1 |pages= 46–53 |year= 2002 |pmid= 11869808 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ofman R, Ruiter JP, Feenstra M, "et al." |title=2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency is caused by mutations in the HADH2 gene. |journal=Am. J. Hum. Genet. |volume=72 |issue= 5 |pages= 1300–7 |year= 2003 |pmid= 12696021 |doi=
*cite journal | author=Shafqat N, Marschall HU, Filling C, "et al." |title=Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD. |journal=Biochem. J. |volume=376 |issue= Pt 1 |pages= 49–60 |year= 2003 |pmid= 12917011 |doi= 10.1042/BJ20030877

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