CYP7B1

CYP7B1

Cytochrome P450, family 7, subfamily B, polypeptide 1, also known as CYP7B1, is a human gene.cite web | title = Entrez Gene: CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9420| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.cite web | title = Entrez Gene: CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9420| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schwarz M, Lund EG, Russell DW |title=Two 7 alpha-hydroxylase enzymes in bile acid biosynthesis. |journal=Curr. Opin. Lipidol. |volume=9 |issue= 2 |pages= 113–8 |year= 1998 |pmid= 9559267 |doi=
*cite journal | author=Hennebert O, Chalbot S, Alran S, Morfin R |title=Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes. |journal=J. Steroid Biochem. Mol. Biol. |volume=104 |issue= 3-5 |pages= 326–33 |year= 2007 |pmid= 17467270 |doi= 10.1016/j.jsbmb.2007.03.026
*cite journal | author=Tang W, Norlin M |title=Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 2 |pages= 540–6 |year= 2006 |pmid= 16630558 |doi= 10.1016/j.bbrc.2006.03.175
*cite journal | author=Dulos J, van der Vleuten MA, Kavelaars A, "et al." |title=CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. |journal=Arthritis Rheum. |volume=52 |issue= 3 |pages= 770–8 |year= 2005 |pmid= 15751070 |doi= 10.1002/art.20950
*cite journal | author=Kim SB, Chalbot S, Pompon D, "et al." |title=The human cytochrome P4507B1: catalytic activity studies. |journal=J. Steroid Biochem. Mol. Biol. |volume=92 |issue= 5 |pages= 383–9 |year= 2005 |pmid= 15698543 |doi= 10.1016/j.jsbmb.2004.09.005
*cite journal | author=Martin C, Ross M, Chapman KE, "et al." |title=CYP7B generates a selective estrogen receptor beta agonist in human prostate. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 6 |pages= 2928–35 |year= 2004 |pmid= 15181079 |doi= 10.1210/jc.2003-031847
*cite journal | author=Jakobsson J, Karypidis H, Johansson JE, "et al." |title=A functional C-G polymorphism in the CYP7B1 promoter region and its different distribution in Orientals and Caucasians. |journal=Pharmacogenomics J. |volume=4 |issue= 4 |pages= 245–50 |year= 2005 |pmid= 15007371 |doi= 10.1038/sj.tpj.6500236
*cite journal | author=Norlin M, Chiang JY |title=Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 1 |pages= 158–64 |year= 2004 |pmid= 15003524 |doi= 10.1016/j.bbrc.2004.02.029
*cite journal | author=Yau JL, Rasmuson S, Andrew R, "et al." |title=Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease. |journal=Neuroscience |volume=121 |issue= 2 |pages= 307–14 |year= 2003 |pmid= 14521990 |doi=
*cite journal | author=Saito S, Iida A, Sekine A, "et al." |title=Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. |journal=J. Hum. Genet. |volume=48 |issue= 5 |pages= 249–70 |year= 2003 |pmid= 12721789 |doi= 10.1007/s10038-003-0021-7
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wu Z, Martin KO, Javitt NB, Chiang JY |title=Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1. |journal=J. Lipid Res. |volume=40 |issue= 12 |pages= 2195–203 |year= 2000 |pmid= 10588945 |doi=
*cite journal | author=Setchell KD, Schwarz M, O'Connell NC, "et al." |title=Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease. |journal=J. Clin. Invest. |volume=102 |issue= 9 |pages= 1690–703 |year= 1998 |pmid= 9802883 |doi=

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