11beta-hydroxysteroid dehydrogenase

In enzymology, a 11beta-hydroxysteroid dehydrogenase (EC number|1.1.1.146) is an enzyme that catalyzes the chemical reaction

:an 11beta-hydroxysteroid + NADP⁺ $ightleftharpoons$ an 11-oxosteroid + NADPH + H⁺

Thus, the two substrates of this enzyme are 11beta-hydroxysteroid and NADP⁺, whereas its 3 products are 11-oxosteroid, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 11beta-hydroxysteroid:NADP+ 11-oxidoreductase. Other names in common use include corticosteroid 11beta-dehydrogenase, beta-hydroxysteroid dehydrogenase, 11beta-hydroxy steroid dehydrogenase, corticosteroid 11-reductase, and dehydrogenase, 11beta-hydroxy steroid. This enzyme participates in c21-steroid hormone metabolism and androgen and estrogen metabolism.

tructural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1XSE, PDB link|1XU7, PDB link|1XU9, PDB link|1Y5M, PDB link|1Y5R, PDB link|2BEL, PDB link|2ILT, and PDB link|2IRW.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9041-46-7."

Gene Ontology (GO) codes