(R)-2-hydroxyacid dehydrogenase

In enzymology, a (R)-2-hydroxyacid dehydrogenase (EC number|1.1.1.272) is an enzyme that catalyzes the chemical reaction

:(2R)-3-sulfolactate + NAD(P)+ $ightleftharpoons$ 3-sulfopyruvate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (2R)-3-sulfolactic acid, NAD⁺, and NADP⁺, whereas its 4 products are 3-sulfopyruvic acid, NADH, NADPH, and H⁺. This enzyme is important in the metabolism of archaea, particularly their biosynthesis of coenzymes such as coenzyme M, tetrahydromethanopterin and methanofuran. [cite journal | author = Graupner M, Xu H, White RH | date = 2000 | title = Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea | journal = J. Bacteriol. | volume = 182 | pages = 3688–92 | pmid = 10850983 | doi = 10.1128/JB.182.13.3688-3692.2000 ]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-2-hydroxyacid:NAD(P)+ oxidoreductase. Other names in common use include (R)-sulfolactate:NAD(P)+ oxidoreductase, L-sulfolactate dehydrogenase, ComC, and (R)-sulfolactate dehydrogenase.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1RFM.

References

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External links

Gene Ontology (GO) codes