4-hydroxybutyrate dehydrogenase
- 4-hydroxybutyrate dehydrogenase
In enzymology, a 4-hydroxybutyrate dehydrogenase (EC number|1.1.1.61) is an enzyme that catalyzes the chemical reaction
:4-hydroxybutanoate + NAD+ succinate semialdehyde + NADH + H+
The two substrates of this enzyme are therefore 4-hydroxybutanoic acid, and NAD+, whereas its 3 products are succinate semialdehyde, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. [cite journal | author = Nirenberg MW and Jakoby WB | date = 1960 | title = Enzymatic utilization of gamma-hydroxybutyric acid | journal = J. Biol. Chem. | volume = 235 | pages = 954–960 ] The systematic name of this enzyme class is 4-hydroxybutanoate:NAD+ oxidoreductase. This enzyme is also called gamma-hydroxybutyrate dehydrogenase. This enzyme participates in butanoate metabolism and the degradation of the neurotransmitter 4-hydroxybutanoic acid. [cite journal |author=Kaufman EE, Nelson T |title=An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP(+)-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway |journal=Neurochem. Res. |volume=16 |issue=9 |pages=965–74 |year=1991 |pmid=1784339 |doi=10.1007/BF00965839]
References
External links
Gene Ontology (GO) codes
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