Glyoxylate reductase/hydroxypyruvate reductase, also known as GRHPR, is a human gene.cite web | title = Entrez Gene: GRHPR glyoxylate reductase/hydroxypyruvate reductase| url =| accessdate = ]

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.cite web | title = Entrez Gene: GRHPR glyoxylate reductase/hydroxypyruvate reductase| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Takayama T, Nagata M, Ozono S, "et al." |title=A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2. |journal=Nephrol. Dial. Transplant. |volume=22 |issue= 8 |pages= 2371–4 |year= 2007 |pmid= 17510093 |doi= 10.1093/ndt/gfm271
*cite journal | author=Booth MP, Conners R, Rumsby G, Brady RL |title=Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase. |journal=J. Mol. Biol. |volume=360 |issue= 1 |pages= 178–89 |year= 2006 |pmid= 16756993 |doi= 10.1016/j.jmb.2006.05.018
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Webster KE, Ferree PM, Holmes RP, Cramer SD |title=Identification of missense, nonsense, and deletion mutations in the GRHPR gene in patients with primary hyperoxaluria type II (PH2). |journal=Hum. Genet. |volume=107 |issue= 2 |pages= 176–85 |year= 2000 |pmid= 11030416 |doi=
*cite journal | author=Huang T, Yang W, Pereira AC, "et al." |title=Cloning and characterization of a putative human d-2-hydroxyacid dehydrogenase in chromosome 9q. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 298–301 |year= 2000 |pmid= 10679197 |doi= 10.1006/bbrc.2000.2122
*cite journal | author=Rumsby G, Cregeen DP |title=Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase. |journal=Biochim. Biophys. Acta |volume=1446 |issue= 3 |pages= 383–8 |year= 1999 |pmid= 10524214 |doi=
*cite journal | author=Cramer SD, Ferree PM, Lin K, "et al." |title=The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. |journal=Hum. Mol. Genet. |volume=8 |issue= 11 |pages= 2063–9 |year= 1999 |pmid= 10484776 |doi=

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