3-hydroxyacyl-CoA dehydrogenase

In enzymology, a 3-hydroxyacyl-CoA dehydrogenase (EC number|1.1.1.35) is an enzyme that catalyzes the chemical reaction

:(S)-3-hydroxyacyl-CoA + NAD⁺ $ightleftharpoons$ 3-oxoacyl-CoA + NADH + H⁺

Thus, the two substrates of this enzyme are (S)-3-hydroxyacyl-CoA and NAD⁺, whereas its 3 products are 3-oxoacyl-CoA, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase. Other names in common use include beta-hydroxyacyl dehydrogenase, beta-keto-reductase, 3-keto reductase, 3-hydroxyacyl coenzyme A dehydrogenase, beta-hydroxyacyl-coenzyme A synthetase, beta-hydroxyacylcoenzyme A dehydrogenase, beta-hydroxybutyrylcoenzyme A dehydrogenase, 3-hydroxyacetyl-coenzyme A dehydrogenase, L-3-hydroxyacyl coenzyme A dehydrogenase, L-3-hydroxyacyl CoA dehydrogenase, beta-hydroxyacyl CoA dehydrogenase, 3beta-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxybutyryl-CoA dehydrogenase, beta-ketoacyl-CoA reductase, beta-hydroxy acid dehydrogenase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-hydroxyisobutyryl-CoA dehydrogenase, and 1-specific DPN-linked beta-hydroxybutyric dehydrogenase. This enzyme participates in 8 metabolic pathways: fatty acid elongation in mitochondria, fatty acid metabolism, valine, leucine and isoleucine degradation, lysine degradation, tryptophan metabolism, benzoate degradation via coa ligation, butanoate metabolism, and caprolactam degradation.

tructural studies

As of late 2007, 24 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1E3S, PDB link|1E3W, PDB link|1E6W, PDB link|1F0Y, PDB link|1F12, PDB link|1F14, PDB link|1F17, PDB link|1IL0, PDB link|1LSJ, PDB link|1LSO, PDB link|1M75, PDB link|1M76, PDB link|1SO8, PDB link|1U7T, PDB link|1WDK, PDB link|1WDL, PDB link|1WDM, PDB link|1ZBQ, PDB link|1ZCJ, PDB link|1ZEJ, PDB link|2D3T, PDB link|2HDH, PDB link|3HAD, and PDB link|3HDH.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-40-4."

Gene Ontology (GO) codes