Butyryl-CoA dehydrogenase

In enzymology, a butyryl-CoA dehydrogenase (EC number|1.3.99.2) is an enzyme that catalyzes the chemical reaction

:butanoyl-CoA + acceptor $ightleftharpoons$ 2-butenoyl-CoA + reduced acceptor

Thus, the two substrates of this enzyme are butanoyl-CoA and acceptor, whereas its two products are 2-butenoyl-CoA and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is butanoyl-CoA:acceptor 2,3-oxidoreductase. Other names in common use include butyryl dehydrogenase, unsaturated acyl-CoA reductase, ethylene reductase, enoyl-coenzyme A reductase, unsaturated acyl coenzyme A reductase, butyryl coenzyme A dehydrogenase, short-chain acyl CoA dehydrogenase, short-chain acyl-coenzyme A dehydrogenase, 3-hydroxyacyl CoA reductase, and butanoyl-CoA:(acceptor) 2,3-oxidoreductase. This enzyme participates in 3 metabolic pathways: fatty acid metabolism, valine, leucine and isoleucine degradation, and butanoate metabolism. It employs one cofactor, FAD.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1BUC and PDB link|1JQI.

References

* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 447-466.
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External links

::"The CAS registry number for this enzyme class is CAS registry|9027-88-7."

Gene Ontology (GO) codes