- TLN1
Talin 1, also known as TLN1, is a human
gene .PBB_Summary
section_title =
summary_text = This gene encodes a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [cite web | title = Entrez Gene: TLN1 talin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7094| accessdate = ]ee also
*
Talin protein References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Luna EJ, Hitt AL |title=Cytoskeleton--plasma membrane interactions. |journal=Science |volume=258 |issue= 5084 |pages= 955–64 |year= 1992 |pmid= 1439807 |doi=
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Critchley DR |title=Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 5 |pages= 831–6 |year= 2005 |pmid= 15494027 |doi= 10.1042/BST0320831PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
Wikimedia Foundation. 2010.
