FLNC (gene)

Filamin C, gamma (actin binding protein 280), also known as FLNC, is a human gene.cite web | title = Entrez Gene: FLNC filamin C, gamma (actin binding protein 280)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2318| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain.cite web | title = Entrez Gene: FLNC filamin C, gamma (actin binding protein 280)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2318| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Stossel TP, Condeelis J, Cooley L, "et al." |title=Filamins as integrators of cell mechanics and signalling. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 2 |pages= 138–45 |year= 2001 |pmid= 11252955 |doi= 10.1038/35052082
*cite journal | author=Maestrini E, Patrosso C, Mancini M, "et al." |title=Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7. |journal=Hum. Mol. Genet. |volume=2 |issue= 6 |pages= 761–6 |year= 1993 |pmid= 7689010 |doi=
*cite journal | author=Gariboldi M, Maestrini E, Canzian F, "et al." |title=Comparative mapping of the actin-binding protein 280 genes in human and mouse. |journal=Genomics |volume=21 |issue= 2 |pages= 428–30 |year= 1994 |pmid= 8088838 |doi=
*cite journal | author=Lanfranchi G, Muraro T, Caldara F, "et al." |title=Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization. |journal=Genome Res. |volume=6 |issue= 1 |pages= 35–42 |year= 1996 |pmid= 8681137 |doi=
*cite journal | author=Marti A, Luo Z, Cunningham C, "et al." |title=Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2620–8 |year= 1997 |pmid= 9006895 |doi=
*cite journal | author=Liu G, Thomas L, Warren RA, "et al." |title=Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. |journal=J. Cell Biol. |volume=139 |issue= 7 |pages= 1719–33 |year= 1998 |pmid= 9412467 |doi=
*cite journal | author=Xu W, Xie Z, Chung DW, Davie EW |title=A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha. |journal=Blood |volume=92 |issue= 4 |pages= 1268–76 |year= 1998 |pmid= 9694715 |doi=
*cite journal | author=Xie Z, Xu W, Davie EW, Chung DW |title=Molecular cloning of human ABPL, an actin-binding protein homologue. |journal=Biochem. Biophys. Res. Commun. |volume=251 |issue= 3 |pages= 914–9 |year= 1998 |pmid= 9791010 |doi=
*cite journal | author=Thompson TG, Chan YM, Hack AA, "et al." |title=Filamin 2 (FLN2): A muscle-specific sarcoglycan interacting protein. |journal=J. Cell Biol. |volume=148 |issue= 1 |pages= 115–26 |year= 2000 |pmid= 10629222 |doi=
*cite journal | author=van der Ven PF, Obermann WM, Lemke B, "et al." |title=Characterization of muscle filamin isoforms suggests a possible role of gamma-filamin/ABP-L in sarcomeric Z-disc formation. |journal=Cell Motil. Cytoskeleton |volume=45 |issue= 2 |pages= 149–62 |year= 2000 |pmid= 10658210 |doi= 10.1002/(SICI)1097-0169(200002)45:2<149::AID-CM6>3.0.CO;2-G |doilabel=10.1002/(SICI)1097-0169(200002)45:2149::AID-CM63.0.CO;2-G
*cite journal | author=Faulkner G, Pallavicini A, Comelli A, "et al." |title=FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle. |journal=J. Biol. Chem. |volume=275 |issue= 52 |pages= 41234–42 |year= 2001 |pmid= 10984498 |doi= 10.1074/jbc.M007493200
*cite journal | author=van der Ven PF, Wiesner S, Salmikangas P, "et al." |title=Indications for a novel muscular dystrophy pathway. gamma-filamin, the muscle-specific filamin isoform, interacts with myotilin. |journal=J. Cell Biol. |volume=151 |issue= 2 |pages= 235–48 |year= 2000 |pmid= 11038172 |doi=
*cite journal | author=Petrecca K, Miller DM, Shrier A |title=Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin. |journal=J. Neurosci. |volume=20 |issue= 23 |pages= 8736–44 |year= 2001 |pmid= 11102480 |doi=
*cite journal | author=Chakarova C, Wehnert MS, Uhl K, "et al." |title=Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family. |journal=Hum. Genet. |volume=107 |issue= 6 |pages= 597–611 |year= 2001 |pmid= 11153914 |doi=
*cite journal | author=Takada F, Vander Woude DL, Tong HQ, "et al." |title=Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1595–600 |year= 2001 |pmid= 11171996 |doi= 10.1073/pnas.041609698
*cite journal | author=Dyson JM, O'Malley CJ, Becanovic J, "et al." |title=The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin. |journal=J. Cell Biol. |volume=155 |issue= 6 |pages= 1065–79 |year= 2002 |pmid= 11739414 |doi= 10.1083/jcb.200104005
*cite journal | author=Frey N, Olson EN |title=Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13998–4004 |year= 2002 |pmid= 11842093 |doi= 10.1074/jbc.M200712200
*cite journal | author=Donaldson JC, Dise RS, Ritchie MD, Hanks SK |title=Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29028–35 |year= 2002 |pmid= 12006559 |doi= 10.1074/jbc.M111697200
*cite journal | author=Shoeman RL, Hartig R, Hauses C, Traub P |title=Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease. |journal=Cell Biol. Int. |volume=26 |issue= 6 |pages= 529–39 |year= 2003 |pmid= 12119179 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes