Cofilin 1

Cofilin 1
Cofilin 1 (non-muscle)

PDB rendering based on 1q8g.
Identifiers
Symbols CFL1; CFL
External IDs OMIM601442 MGI101757 HomoloGene99735 GeneCards: CFL1 Gene
RNA expression pattern
PBB GE CFL1 200021 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1072 12631
Ensembl ENSG00000172757 ENSMUSG00000056201
UniProt P23528 Q544Y7
RefSeq (mRNA) NM_005507.2 NM_007687.5
RefSeq (protein) NP_005498.1 NP_031713.1
Location (UCSC) Chr 11:
65.59 – 65.63 Mb
Chr 19:
5.49 – 5.49 Mb
PubMed search [1] [2]

Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family.

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[1]

One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.[2][3]

Interactions

Cofilin 1 has been shown to interact with HSPH1[4] and LIMK1.[5][6]

References

  1. ^ "Entrez Gene: CFL1 cofilin 1 (non-muscle)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1072. 
  2. ^ Chai X, Förster E, Zhao S, Bock HH, Frotscher M (January 2009). "Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3". J. Neurosci. 29 (1): 288–99. doi:10.1523/JNEUROSCI.2934-08.2009. PMID 19129405. http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=19129405. 
  3. ^ Frotscher M, Chai X, Bock HH, Haas CA, Förster E, Zhao S (April 2009). "Role of Reelin in the development and maintenance of cortical lamination". J Neural Transm 116 (11): 1451–5. doi:10.1007/s00702-009-0228-7. PMID 19396394. 
  4. ^ Saito, Youhei; Doi Kazuya, Yamagishi Nobuyuki, Ishihara Keiichi, Hatayama Takumi (Feb. 2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochem. Biophys. Res. Commun. (United States) 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. ISSN 0006-291X. PMID 14733918. 
  5. ^ Foletta, Victoria C; Lim Mei Ann, Soosairajah Juliana, Kelly April P, Stanley Edouard G, Shannon Mark, He Wei, Das Supratik, Massague Joan, Bernard Ora, Soosairaiah Juliana (Sep. 2003). "Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1". J. Cell Biol. (United States) 162 (6): 1089–98. doi:10.1083/jcb.200212060. ISSN 0021-9525. PMC 2172847. PMID 12963706. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172847. 
  6. ^ Maekawa, M; Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S (Aug. 1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase". Science (UNITED STATES) 285 (5429): 895–8. doi:10.1126/science.285.5429.895. ISSN 0036-8075. PMID 10436159. 

Further reading


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Look at other dictionaries:

  • cofilin — cofilin. См. кофилин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Cofilin — Cartoon representation of a cofilin (actin depolymerizing factor, ADF). ADF/cofilin is a family of actin binding proteins which disassembles actin filaments. Three highly conserved and highly (70% 82%) identical genes belonging to this family… …   Wikipedia

  • cofilin — Actin severing protein (19 kD), related to destrin. Binds to the side of filaments and is pH sensitive. Shares with tropomyosin a 13 amino acid F actin binding domain. Very similar to ADF (actin depolymerizing factor) …   Dictionary of molecular biology

  • cofilin — noun Any of a class of proteins which disassemble actin filaments …   Wiktionary

  • N-cofilin — …   Википедия

  • кофилин — cofilin кофилин. Белок, модулирующий действие актина <actin>, часто присутствует в нервных, мышечных и некоторых других тканях, чувствителен к изменению рН; у мыши полипептидная цепь К. состоит из 166 аминокислот. (Источник: «Англо русский… …   Молекулярная биология и генетика. Толковый словарь.

  • SSH1 — Slingshot homolog 1 (Drosophila), also known as SSH1, is a human gene.cite web | title = Entrez Gene: SSH1 slingshot homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=54434| accessdate …   Wikipedia

  • SSH2 — For the SSH 2 protocol, see Secure Shell Slingshot homolog 2 (Drosophila), also known as SSH2, is a human gene.cite web | title = Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • SSH3 — Slingshot homolog 3 (Drosophila), also known as SSH3, is a human gene.cite web | title = Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=54961| accessdate …   Wikipedia

  • Кофилин 1 — Обозначения Символы CFL1; CFL Entrez Gene …   Википедия

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