LIMK1

LIM domain kinase 1, also known as LIMK1, is a human gene.

PBB_Summary
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summary_text = There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.cite web | title = Entrez Gene: LIMK1 LIM domain kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3984| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Scott RW, Olson MF |title=LIM kinases: function, regulation and association with human disease. |journal=J. Mol. Med. |volume=85 |issue= 6 |pages= 555–68 |year= 2007 |pmid= 17294230 |doi= 10.1007/s00109-007-0165-6
*cite journal | author=Mizuno K, Okano I, Ohashi K, "et al." |title=Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif. |journal=Oncogene |volume=9 |issue= 6 |pages= 1605–12 |year= 1994 |pmid= 8183554 |doi=
*cite journal | author=Okano I, Hiraoka J, Otera H, "et al." |title=Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs. |journal=J. Biol. Chem. |volume=270 |issue= 52 |pages= 31321–30 |year= 1996 |pmid= 8537403 |doi=
*cite journal | author=Tassabehji M, Metcalfe K, Fergusson WD, "et al." |title=LIM-kinase deleted in Williams syndrome. |journal=Nat. Genet. |volume=13 |issue= 3 |pages= 272–3 |year= 1996 |pmid= 8673124 |doi= 10.1038/ng0796-272
*cite journal | author=Frangiskakis JM, Ewart AK, Morris CA, "et al." |title=LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition. |journal=Cell |volume=86 |issue= 1 |pages= 59–69 |year= 1996 |pmid= 8689688 |doi=
*cite journal | author=Osborne LR, Martindale D, Scherer SW, "et al." |title=Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. |journal=Genomics |volume=36 |issue= 2 |pages= 328–36 |year= 1997 |pmid= 8812460 |doi= 10.1006/geno.1996.0469
*cite journal | author=Nebl G, Meuer SC, Samstag Y |title=Dephosphorylation of serine 3 regulates nuclear translocation of cofilin. |journal=J. Biol. Chem. |volume=271 |issue= 42 |pages= 26276–80 |year= 1996 |pmid= 8824278 |doi=
*cite journal | author=Hiraoka J, Okano I, Higuchi O, "et al." |title=Self-association of LIM-kinase 1 mediated by the interaction between an N-terminal LIM domain and a C-terminal kinase domain. |journal=FEBS Lett. |volume=399 |issue= 1-2 |pages= 117–21 |year= 1997 |pmid= 8980133 |doi=
*cite journal | author=Yang N, Higuchi O, Ohashi K, "et al." |title=Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. |journal=Nature |volume=393 |issue= 6687 |pages= 809–12 |year= 1998 |pmid= 9655398 |doi= 10.1038/31735
*cite journal | author=Wang JY, Frenzel KE, Wen D, Falls DL |title=Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition. |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20525–34 |year= 1998 |pmid= 9685409 |doi=
*cite journal | author=Edwards DC, Gill GN |title=Structural features of LIM kinase that control effects on the actin cytoskeleton. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11352–61 |year= 1999 |pmid= 10196227 |doi=
*cite journal | author=Sotiropoulos A, Gineitis D, Copeland J, Treisman R |title=Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. |journal=Cell |volume=98 |issue= 2 |pages= 159–69 |year= 1999 |pmid= 10428028 |doi=
*cite journal | author=Bach I, Rodriguez-Esteban C, Carrière C, "et al." |title=RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 394–9 |year= 1999 |pmid= 10431247 |doi= 10.1038/11970
*cite journal | author=Maekawa M, Ishizaki T, Boku S, "et al." |title=Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. |journal=Science |volume=285 |issue= 5429 |pages= 895–8 |year= 1999 |pmid= 10436159 |doi=
*cite journal | author=Edwards DC, Sanders LC, Bokoch GM, Gill GN |title=Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. |journal=Nat. Cell Biol. |volume=1 |issue= 5 |pages= 253–9 |year= 1999 |pmid= 10559936 |doi= 10.1038/12963
*cite journal | author=Ohashi K, Nagata K, Maekawa M, "et al." |title=Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3577–82 |year= 2000 |pmid= 10652353 |doi=
*cite journal | author=Martindale DW, Wilson MD, Wang D, "et al." |title=Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 890–8 |year= 2000 |pmid= 11003705 |doi=
*cite journal | author=Sumi T, Matsumoto K, Shibuya A, Nakamura T |title=Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 23092–6 |year= 2001 |pmid= 11340065 |doi= 10.1074/jbc.C100196200
*cite journal | author=Dan C, Kelly A, Bernard O, Minden A |title=Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32115–21 |year= 2001 |pmid= 11413130 |doi= 10.1074/jbc.M100871200
*cite journal | author=Toshima J, Toshima JY, Takeuchi K, "et al." |title=Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31449–58 |year= 2001 |pmid= 11418599 |doi= 10.1074/jbc.M102988200

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