ILF3

Interleukin enhancer binding factor 3, 90kDa, also known as ILF3, is a human gene.

PBB_Summary
section_title =
summary_text = Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of interleukin 2. NFAT binds to a sequence in the IL2 enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. The encoded protein, which is primarily localized to ribosomes, probably regulates transcription at the level of mRNA elongation. At least three transcript variants encoding three different isoforms have been found for this gene.cite web | title = Entrez Gene: ILF3 interleukin enhancer binding factor 3, 90kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3609| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=St Johnston D, Brown NH, Gall JG, Jantsch M |title=A conserved double-stranded RNA-binding domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 22 |pages= 10979–83 |year= 1992 |pmid= 1438302 |doi=
*cite journal | author=Kao PN, Chen L, Brock G, "et al." |title=Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. |journal=J. Biol. Chem. |volume=269 |issue= 32 |pages= 20691–9 |year= 1994 |pmid= 7519613 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Matsumoto-Taniura N, Pirollet F, Monroe R, "et al." |title=Identification of novel M phase phosphoproteins by expression cloning. |journal=Mol. Biol. Cell |volume=7 |issue= 9 |pages= 1455–69 |year= 1997 |pmid= 8885239 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Ting NS, Kao PN, Chan DW, "et al." |title=DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. |journal=J. Biol. Chem. |volume=273 |issue= 4 |pages= 2136–45 |year= 1998 |pmid= 9442054 |doi=
*cite journal | author=Marcoulatos P, Avgerinos E, Tsantzalos DV, Vamvakopoulos NC |title=Mapping interleukin enhancer binding factor 3 gene (ILF3) to human chromosome 19 (19q11-qter and 19p11-p13.1) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates. |journal=J. Interferon Cytokine Res. |volume=18 |issue= 5 |pages= 351–5 |year= 1998 |pmid= 9620363 |doi=
*cite journal | author=Aoki Y, Zhao G, Qiu D, "et al." |title=CsA-sensitive purine-box transcriptional regulator in bronchial epithelial cells contains NF45, NF90, and Ku. |journal=Am. J. Physiol. |volume=275 |issue= 6 Pt 1 |pages= L1164–72 |year= 1999 |pmid= 9843854 |doi=
*cite journal | author=Langland JO, Kao PN, Jacobs BL |title=Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR. |journal=Biochemistry |volume=38 |issue= 19 |pages= 6361–8 |year= 1999 |pmid= 10320367 |doi= 10.1021/bi982410u
*cite journal | author=Patel RC, Vestal DJ, Xu Z, "et al." |title=DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR. |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20432–7 |year= 1999 |pmid= 10400669 |doi=
*cite journal | author=Satoh M, Shaheen VM, Kao PN, "et al." |title=Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity. |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 34598–604 |year= 2000 |pmid= 10574923 |doi=
*cite journal | author=Xu YH, Grabowski GA |title=Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs. |journal=Mol. Genet. Metab. |volume=68 |issue= 4 |pages= 441–54 |year= 2000 |pmid= 10607473 |doi= 10.1006/mgme.1999.2934
*cite journal | author=Coolidge CJ, Patton JG |title=A new double-stranded RNA-binding protein that interacts with PKR. |journal=Nucleic Acids Res. |volume=28 |issue= 6 |pages= 1407–17 |year= 2000 |pmid= 10684936 |doi=
*cite journal | author=Tang J, Kao PN, Herschman HR |title=Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19866–76 |year= 2000 |pmid= 10749851 |doi= 10.1074/jbc.M000023200
*cite journal | author=Saunders LR, Jurecic V, Barber GN |title=The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13. |journal=Genomics |volume=71 |issue= 2 |pages= 256–9 |year= 2001 |pmid= 11161820 |doi= 10.1006/geno.2000.6423
*cite journal | author=Duchange N, Pidoux J, Camus E, Sauvaget D |title=Alternative splicing in the human interleukin enhancer binding factor 3 (ILF3) gene. |journal=Gene |volume=261 |issue= 2 |pages= 345–53 |year= 2001 |pmid= 11167023 |doi=
*cite journal | author=Saunders LR, Perkins DJ, Balachandran S, "et al." |title=Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32300–12 |year= 2001 |pmid= 11438536 |doi= 10.1074/jbc.M104207200
*cite journal | author=Parker LM, Fierro-Monti I, Mathews MB |title=Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32522–30 |year= 2001 |pmid= 11438540 |doi= 10.1074/jbc.M104408200
*cite journal | author=Reichman TW, Muñiz LC, Mathews MB |title=The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells. |journal=Mol. Cell. Biol. |volume=22 |issue= 1 |pages= 343–56 |year= 2002 |pmid= 11739746 |doi=

External links

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