TUBA1A

TUBA1A

Tubulin, alpha 1a, also known as TUBA1A, is a human gene.cite web | title = Entrez Gene: TUBA1A tubulin, alpha 1a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7846| accessdate = ]

PBB_Summary
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summary_text = Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.cite web | title = Entrez Gene: TUBA1A tubulin, alpha 1a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7846| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Desai A, Mitchison TJ |title=Tubulin and FtsZ structures: functional and therapeutic implications. |journal=Bioessays |volume=20 |issue= 7 |pages= 523–7 |year= 1998 |pmid= 9722999 |doi= 10.1002/(SICI)1521-1878(199807)20:7<523::AID-BIES1>3.0.CO;2-L |doilabel=10.1002/(SICI)1521-1878(199807)20:7523::AID-BIES13.0.CO;2-L
*cite journal | author=Oakley BR |title=An abundance of tubulins. |journal=Trends Cell Biol. |volume=10 |issue= 12 |pages= 537–42 |year= 2001 |pmid= 11121746 |doi=
*cite journal | author=Dutcher SK |title=The tubulin fraternity: alpha to eta. |journal=Curr. Opin. Cell Biol. |volume=13 |issue= 1 |pages= 49–54 |year= 2001 |pmid= 11163133 |doi=
*cite journal | author=Miller FD, Naus CC, Durand M, "et al." |title=Isotypes of alpha-tubulin are differentially regulated during neuronal maturation. |journal=J. Cell Biol. |volume=105 |issue= 6 Pt 2 |pages= 3065–73 |year= 1988 |pmid= 3693406 |doi=
*cite journal | author=Hall JL, Cowan NJ |title=Structural features and restricted expression of a human alpha-tubulin gene. |journal=Nucleic Acids Res. |volume=13 |issue= 1 |pages= 207–23 |year= 1985 |pmid= 3839072 |doi=
*cite journal | author=Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW |title=Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. |journal=Mol. Cell. Biol. |volume=3 |issue= 10 |pages= 1738–45 |year= 1984 |pmid= 6646120 |doi=
*cite journal | author=Alexandrova N, Niklinski J, Bliskovsky V, "et al." |title=The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5188–95 |year= 1995 |pmid= 7651436 |doi=
*cite journal | author=Sapir T, Elbaum M, Reiner O |title=Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. |journal=EMBO J. |volume=16 |issue= 23 |pages= 6977–84 |year= 1998 |pmid= 9384577 |doi= 10.1093/emboj/16.23.6977
*cite journal | author=Kinnunen T, Kaksonen M, Saarinen J, "et al." |title=Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth. |journal=J. Biol. Chem. |volume=273 |issue= 17 |pages= 10702–8 |year= 1998 |pmid= 9553134 |doi=
*cite journal | author=Faruki S, Geahlen RL, Asai DJ |title=Syk-dependent phosphorylation of microtubules in activated B-lymphocytes. |journal=J. Cell. Sci. |volume=113 ( Pt 14) |issue= |pages= 2557–65 |year= 2000 |pmid= 10862713 |doi=
*cite journal | author=Watts NR, Sackett DL, Ward RD, "et al." |title=HIV-1 rev depolymerizes microtubules to form stable bilayered rings. |journal=J. Cell Biol. |volume=150 |issue= 2 |pages= 349–60 |year= 2000 |pmid= 10908577 |doi=
*cite journal | author=Germani A, Bruzzoni-Giovanelli H, Fellous A, "et al." |title=SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. |journal=Oncogene |volume=19 |issue= 52 |pages= 5997–6006 |year= 2001 |pmid= 11146551 |doi= 10.1038/sj.onc.1204002
*cite journal | author=Crabtree DV, Ojima I, Geng X, Adler AJ |title=Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site. |journal=Bioorg. Med. Chem. |volume=9 |issue= 8 |pages= 1967–76 |year= 2001 |pmid= 11504633 |doi=
*cite journal | author=Payton JE, Perrin RJ, Clayton DF, George JM |title=Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells. |journal=Brain Res. Mol. Brain Res. |volume=95 |issue= 1-2 |pages= 138–45 |year= 2002 |pmid= 11687285 |doi=
*cite journal | author=Bifulco M, Laezza C, Stingo S, Wolff J |title=2',3'-Cyclic nucleotide 3'-phosphodiesterase: a membrane-bound, microtubule-associated protein and membrane anchor for tubulin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 4 |pages= 1807–12 |year= 2002 |pmid= 11842207 |doi= 10.1073/pnas.042678799
*cite journal | author=Saugstad JA, Yang S, Pohl J, "et al." |title=Interaction between metabotropic glutamate receptor 7 and alpha tubulin. |journal=J. Neurochem. |volume=80 |issue= 6 |pages= 980–8 |year= 2002 |pmid= 11953448 |doi=
*cite journal | author=Ivings L, Pennington SR, Jenkins R, "et al." |title=Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin. |journal=Biochem. J. |volume=363 |issue= Pt 3 |pages= 599–608 |year= 2002 |pmid= 11964161 |doi=

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