Zyxin

Zyxin

Zyxin, also known as ZYX, is a human gene.cite web | title = Entrez Gene: ZYX zyxin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7791| accessdate = ]

PBB_Summary
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summary_text = Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.cite web | title = Entrez Gene: ZYX zyxin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7791| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Reinhard M, Jouvenal K, Tripier D, Walter U |title=Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7956–60 |year= 1995 |pmid= 7644520 |doi=
*cite journal | author=Wang LF, Miao SY, Zong SD, "et al." |title=Gene encoding a mammalian epididymal protein. |journal=Biochem. Mol. Biol. Int. |volume=34 |issue= 6 |pages= 1131–6 |year= 1995 |pmid= 7696985 |doi=
*cite journal | author=Hobert O, Schilling JW, Beckerle MC, "et al." |title=SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. |journal=Oncogene |volume=12 |issue= 7 |pages= 1577–81 |year= 1996 |pmid= 8622875 |doi=
*cite journal | author=Zumbrunn J, Trueb B |title=A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts. |journal=Eur. J. Biochem. |volume=241 |issue= 2 |pages= 657–63 |year= 1997 |pmid= 8917469 |doi=
*cite journal | author=Macalma T, Otte J, Hensler ME, "et al." |title=Molecular characterization of human zyxin. |journal=J. Biol. Chem. |volume=271 |issue= 49 |pages= 31470–8 |year= 1997 |pmid= 8940160 |doi=
*cite journal | author=Kotake K, Ozaki N, Mizuta M, "et al." |title=Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells. |journal=J. Biol. Chem. |volume=272 |issue= 47 |pages= 29407–10 |year= 1997 |pmid= 9367993 |doi=
*cite journal | author=Zumbrunn J, Trueb B |title=Assignment of the ZYX gene for the LIM protein zyxin to human chromosome bands 7q34-->q35 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 283–4 |year= 1998 |pmid= 9730620 |doi=
*cite journal | author=Yang JX, Miao SY, Wu YW, "et al." |title=Gene encoding a human testis Sertoli cell component related to LIM domain protein. |journal=Biochem. Mol. Biol. Int. |volume=46 |issue= 1 |pages= 11–9 |year= 1998 |pmid= 9784834 |doi=
*cite journal | author=Reinhard M, Zumbrunn J, Jaquemar D, "et al." |title=An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13410–8 |year= 1999 |pmid= 10224105 |doi=
*cite journal | author=Drees B, Friederich E, Fradelizi J, "et al." |title=Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22503–11 |year= 2000 |pmid= 10801818 |doi= 10.1074/jbc.M001698200
*cite journal | author=Hirota T, Morisaki T, Nishiyama Y, "et al." |title=Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. |journal=J. Cell Biol. |volume=149 |issue= 5 |pages= 1073–86 |year= 2000 |pmid= 10831611 |doi=
*cite journal | author=Smolenski A, Poller W, Walter U, Lohmann SM |title=Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25723–32 |year= 2000 |pmid= 10851246 |doi= 10.1074/jbc.M909632199
*cite journal | author=Harbeck B, Hüttelmaier S, Schluter K, "et al." |title=Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 30817–25 |year= 2000 |pmid= 10882740 |doi= 10.1074/jbc.M005066200
*cite journal | author=Schenker T, Trueb B |title=BSPRY, a novel protein of the Ro-Ret family. |journal=Biochim. Biophys. Acta |volume=1493 |issue= 1-2 |pages= 255–8 |year= 2000 |pmid= 10978534 |doi=
*cite journal | author=Li B, Trueb B |title=Analysis of the alpha-actinin/zyxin interaction. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33328–35 |year= 2001 |pmid= 11423549 |doi= 10.1074/jbc.M100789200
*cite journal | author=Degenhardt YY, Silverstein S |title=Interaction of zyxin, a focal adhesion protein, with the e6 protein from human papillomavirus type 6 results in its nuclear translocation. |journal=J. Virol. |volume=75 |issue= 23 |pages= 11791–802 |year= 2001 |pmid= 11689660 |doi= 10.1128/JVI.75.23.11791-11802.2001
*cite journal | author=Yi J, Kloeker S, Jensen CC, "et al." |title=Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9580–9 |year= 2002 |pmid= 11782456 |doi= 10.1074/jbc.M106922200
*cite journal | author=van der Gaag EJ, Leccia MT, Dekker SK, "et al." |title=Role of zyxin in differential cell spreading and proliferation of melanoma cells and melanocytes. |journal=J. Invest. Dermatol. |volume=118 |issue= 2 |pages= 246–54 |year= 2002 |pmid= 11841540 |doi= 10.1046/j.0022-202x.2001.01657.x
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423

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