ACTN1

Actinin, alpha 1, also known as ACTN1, is a human gene.

PBB_Summary
section_title =
summary_text = Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. [cite web | title = Entrez Gene: ACTN1 actinin, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=87| accessdate = ]

ee also

* Actinin

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease. |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227–30 |year= 1997 |pmid= 8997639 |doi=
*cite journal | author=Menko S, Philp N, Veneziale B, Walker J |title=Integrins and development: how might these receptors regulate differentiation of the lens. |journal=Ann. N. Y. Acad. Sci. |volume=842 |issue= |pages= 36–41 |year= 1998 |pmid= 9599291 |doi=
*cite journal | author=Yürüker B, Niggli V |title=Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network. |journal=J. Cell. Sci. |volume=101 ( Pt 2) |issue= |pages= 403–14 |year= 1992 |pmid= 1629252 |doi=
*cite journal | author=Tokuue Y, Goto S, Imamura M, "et al." |title=Transfection of chicken skeletal muscle alpha-actinin cDNA into nonmuscle and myogenic cells: dimerization is not essential for alpha-actinin to bind to microfilaments. |journal=Exp. Cell Res. |volume=197 |issue= 2 |pages= 158–67 |year= 1992 |pmid= 1720388 |doi=
*cite journal | author=Shoeman RL, Kesselmier C, Mothes E, "et al." |title=Non-viral cellular substrates for human immunodeficiency virus type 1 protease. |journal=FEBS Lett. |volume=278 |issue= 2 |pages= 199–203 |year= 1991 |pmid= 1991513 |doi=
*cite journal | author=Nishiyama M, Ozturk M, Frohlich M, "et al." |title=Expression of human alpha-actinin in human hepatocellular carcinoma. |journal=Cancer Res. |volume=50 |issue= 19 |pages= 6291–4 |year= 1990 |pmid= 2169343 |doi=
*cite journal | author=Youssoufian H, McAfee M, Kwiatkowski DJ |title=Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene. |journal=Am. J. Hum. Genet. |volume=47 |issue= 1 |pages= 62–71 |year= 1990 |pmid= 2349951 |doi=
*cite journal | author=Millake DB, Blanchard AD, Patel B, Critchley DR |title=The cDNA sequence of a human placental alpha-actinin. |journal=Nucleic Acids Res. |volume=17 |issue= 16 |pages= 6725 |year= 1989 |pmid= 2780298 |doi=
*cite journal | author=Dubernard V, Faucher D, Launay JM, Legrand C |title=Identification of the cytoskeletal protein alpha-actinin as a platelet thrombospondin-binding protein. |journal=FEBS Lett. |volume=364 |issue= 2 |pages= 109–14 |year= 1995 |pmid= 7750553 |doi=
*cite journal | author=Knudsen KA, Soler AP, Johnson KR, Wheelock MJ |title=Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin. |journal=J. Cell Biol. |volume=130 |issue= 1 |pages= 67–77 |year= 1995 |pmid= 7790378 |doi=
*cite journal | author=Glück U, Ben-Ze'ev A |title=Modulation of alpha-actinin levels affects cell motility and confers tumorigenicity on 3T3 cells. |journal=J. Cell. Sci. |volume=107 ( Pt 7) |issue= |pages= 1773–82 |year= 1995 |pmid= 7983147 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Egerton M, Moritz RL, Druker B, "et al." |title=Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes. |journal=Biochem. Biophys. Res. Commun. |volume=224 |issue= 3 |pages= 666–74 |year= 1996 |pmid= 8713105 |doi= 10.1006/bbrc.1996.1082
*cite journal | author=Mukai H, Toshimori M, Shibata H, "et al." |title=Interaction of PKN with alpha-actinin. |journal=J. Biol. Chem. |volume=272 |issue= 8 |pages= 4740–6 |year= 1997 |pmid= 9030526 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Hazan RB, Norton L |title=The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 9078–84 |year= 1998 |pmid= 9535896 |doi=
*cite journal | author=Bunn RC, Jensen MA, Reed BC |title=Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. |journal=Mol. Biol. Cell |volume=10 |issue= 4 |pages= 819–32 |year= 1999 |pmid= 10198040 |doi=
*cite journal | author=Reinhard M, Zumbrunn J, Jaquemar D, "et al." |title=An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13410–8 |year= 1999 |pmid= 10224105 |doi=

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