TRIP6

Thyroid hormone receptor interactor 6, also known as TRIP6, is a human gene.cite web | title = Entrez Gene: TRIP6 thyroid hormone receptor interactor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7205| accessdate = ]

PBB_Summary
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summary_text = This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.cite web | title = Entrez Gene: TRIP6 thyroid hormone receptor interactor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7205| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lee JW, Choi HS, Gyuris J, "et al." |title=Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. |journal=Mol. Endocrinol. |volume=9 |issue= 2 |pages= 243–54 |year= 1995 |pmid= 7776974 |doi=
*cite journal | author=Williams JM, Chen GC, Zhu L, Rest RF |title=Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. |journal=Mol. Microbiol. |volume=27 |issue= 1 |pages= 171–86 |year= 1998 |pmid= 9466265 |doi=
*cite journal | author=Yi J, Beckerle MC |title=The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis. |journal=Genomics |volume=49 |issue= 2 |pages= 314–6 |year= 1998 |pmid= 9598321 |doi= 10.1006/geno.1998.5248
*cite journal | author=Murthy KK, Clark K, Fortin Y, "et al." |title=ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E. |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20679–87 |year= 1999 |pmid= 10400701 |doi=
*cite journal | author=Zhao MK, Wang Y, Murphy K, "et al." |title=LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor. |journal=Gene Expr. |volume=8 |issue= 4 |pages= 207–17 |year= 2000 |pmid= 10794523 |doi=
*cite journal | author=Cuppen E, van Ham M, Wansink DG, "et al." |title=The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL. |journal=Eur. J. Cell Biol. |volume=79 |issue= 4 |pages= 283–93 |year= 2000 |pmid= 10826496 |doi=
*cite journal | author=Wilson MD, Riemer C, Martindale DW, "et al." |title=Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. |journal=Nucleic Acids Res. |volume=29 |issue= 6 |pages= 1352–65 |year= 2001 |pmid= 11239002 |doi=
*cite journal | author=Wang Y, Gilmore TD |title=LIM domain protein Trip6 has a conserved nuclear export signal, nuclear targeting sequences, and multiple transactivation domains. |journal=Biochim. Biophys. Acta |volume=1538 |issue= 2-3 |pages= 260–72 |year= 2001 |pmid= 11336797 |doi=
*cite journal | author=Yi J, Kloeker S, Jensen CC, "et al." |title=Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9580–9 |year= 2002 |pmid= 11782456 |doi= 10.1074/jbc.M106922200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zarsky HA, Tarnasky HA, Cheng M, van der Hoorn FA |title=Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1. |journal=Biol. Reprod. |volume=68 |issue= 2 |pages= 543–52 |year= 2003 |pmid= 12533418 |doi=
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Xu J, Lai YJ, Lin WC, Lin FT |title=TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10459–68 |year= 2004 |pmid= 14688263 |doi= 10.1074/jbc.M311891200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Sanz-Rodriguez F, Guerrero-Esteo M, Botella LM, "et al." |title=Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins. |journal=J. Biol. Chem. |volume=279 |issue= 31 |pages= 32858–68 |year= 2004 |pmid= 15148318 |doi= 10.1074/jbc.M400843200
*cite journal | author=Kassel O, Schneider S, Heilbock C, "et al." |title=A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters. |journal=Genes Dev. |volume=18 |issue= 20 |pages= 2518–28 |year= 2004 |pmid= 15489293 |doi= 10.1101/gad.322404
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Li L, Bin LH, Li F, "et al." |title=TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways. |journal=J. Cell. Sci. |volume=118 |issue= Pt 3 |pages= 555–63 |year= 2005 |pmid= 15657077 |doi= 10.1242/jcs.01641
*cite journal | author=Petit MM, Crombez KR, Vervenne HB, "et al." |title=The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins. |journal=FEBS Lett. |volume=579 |issue= 22 |pages= 5061–8 |year= 2005 |pmid= 16137684 |doi= 10.1016/j.febslet.2005.08.012

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